Early life stress is associated with greater default network deactivation during working memory in healthy controls: a preliminary report

被引：0
作者：
Noah S. Philip
Lawrence H. Sweet
Audrey R. Tyrka
Lawrence H. Price
Linda L. Carpenter
Yuliya I. Kuras
Uraina S. Clark
Raymond S. Niaura
机构：
[1] Alpert Medical School of Brown University,Laboratory for Clinical and Translational Neuroscience, Butler Hospital, Department of Psychiatry and Human Behavior
[2] University of Georgia,Department of Psychology
[3] Brown University,Center for Alcohol and Addiction Studies
[4] American Legacy Foundation,undefined
[5] Butler Hospital,undefined
来源：
Brain Imaging and Behavior | 2013年 / 7卷
关键词：
Early life stress; Default network; Working memory; Medial prefrontal cortex; fMRI;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Early life stress (ELS) is a common risk factor for psychopathology, but there are few functional neuroimaging studies investigating its effects. In this preliminary study, we investigated the correlates of ELS exposure on the default network (DN) through measurements of task-associated DN deactivation. Data were analyzed from 19 subjects without psychiatric illness (10 with ELS). Subjects performed the working memory (WM) N-back task (including a 2-back WM and 0-back control condition) while undergoing functional MRI. We compared brain responses in the two groups across 5 bilateral DN regions using an a priori region of interest (ROI) analysis. The ELS group demonstrated significantly greater DN deactivation, observed in the right posterior cingulate cortex PCC, bilateral medial prefrontal cortex, left middle/superior frontal gyrus and right middle temporal region. These preliminary results indicate subjects with ELS demonstrate greater DN deactivations to WM challenges compared to non-ELS controls, potentially reflecting a biomarker of long-term effects of ELS exposure.
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页码：204 / 212
页数：8
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