Biologic basis of bipolar disorder in children and adolescents

被引：4

作者：

Kloos A. ^{[1
]}

Weller E.B. ^{[1
]}

Weller R.A. ^{[1
]}

机构：

[1] Department of Psychiatry, Thomas Jefferson University Hospital, Philadelphia, PA 19107

来源：

Current Psychiatry Reports | 2008年 / 10卷 / 2期

关键词：

Bipolar Disorder; Gray Matter Volume; Bipolar Patient; Acad Child Adolesc Psychiatry; Pediatric Bipolar Disorder;

D O I：

10.1007/s11920-008-0018-1

中图分类号：

学科分类号：

摘要：

Bipolar disorder is a serious and difficult-to-treat condition in any age group. In childhood and adolescence, diagnosis and treatment present specific challenges, as the disorder often manifests in atypical presentations, such as marked irritability and frequent alterations of mood states not typically seen in adults. The lack of double-blind, placebo-controlled studies in pediatric populations also leads to many difficult pharmacologic challenges. In this paper, we review available studies in neuroanatomy, neurochemistry, neurocognitive functioning, and genetics to further explore the underlying neurobiologic mechanisms of child and adolescent bipolar disorder. Future investigation should elicit distinct mechanisms for diagnosing and treating bipolar disorder from a neurobiologic perspective. Copyright © 2008 by Current Medicine Group LLC.

引用

页码：98 / 103

页数：5

共 50 条

[1]

Singh M.K., DelBello M.P., Kowatch R.A., Strakowski S.M., Co-occurrence of bipolar and attention-deficit hyperactivity disorders in children, Bipolar Disord, 8, pp. 710-720, (2006)

[2]

Pavuluri M.N., Birmaher B., Naylor M.W., Pediatric bipolar disorder: A review of the past 10 years, J Am Acad Child Adolesc Psychiatry, 44, pp. 846-871, (2005)

[3]

DelBello M.P., Adler C.M., Strakowski S.M., The neurophysiology of childhood and adolescent bipolar disorder, CNS Spectr, 11, pp. 298-311, (2006)

[4]

Dickstein D.P., Treland J.E., Snow J., Et al., Neuropsychological performance in pediatric bipolar disorder, Biol Psychiatry, 55, pp. 32-39, (2004)

[5]

Caetano S.C., Olvera R.L., Glahn D., Et al., Fronto-limbic brain abnormalities in juvenile onset bipolar disorder, Biol Psychiatry, 58, pp. 525-531, (2005)

[6]

Faraone S.V., Glatt S.J., Tsuang M.T., The genetics of pediatric-onset bipolar disorder, Biol Psychiatry, 53, pp. 970-977, (2003)

[7]

Adler C.M., Adams J., DelBello M.P., Et al., Evidence of white matter pathology in bipolar disorder adolescents experiencing their first episode of mania: A diffusion tensor imaging study, Am J Psychiatry, 163, pp. 322-324, (2006)

[8]

DelBello M.P., Zimmerman M.E., Mills N.P., Et al., Magnetic resonance imaging analysis of amygdala and other subcortical brain regions in adolescents with bipolar disorder, Bipolar Disord, 6, pp. 43-52, (2004)

[9]

Frazier J.A., Chiu S., Breeze J.L., Et al., Structural brain magnetic resonance imaging of limbic and thalamic volumes in pediatric bipolar disorder, Am J Psychiatry, 162, pp. 1256-1265, (2005)

[10]

Frazier J.A., Breeze J.L., Makris N., Et al., Cortical gray matter differences identified by structural magnetic resonance imaging in pediatric bipolar disorder, Bipolar Disord, 7, pp. 555-569, (2005)

← 1 2 3 4 5 →