The diagnosis of brain tuberculoma by 1H-magnetic resonance spectroscopy

被引：0
作者：
Ky Santy
Phang Nan
Yay Chantana
Denis Laurent
David Nadal
Beat Richner
机构：
[1] Jayavarman VII Hospital,Division of Pediatrics
[2] Kantha Bopha Children’s Hospital,Division of Pediatric Imaging
[3] Jayavarman VII Hospital,Division of Pediatric Laboratory Medicine and Microbiology
[4] Kantha Bopha Children’s Hospital,Division of Infectious Diseases and Hospital Epidemiology
[5] Jayavarman VII Hospital,Pediatric Research Center (PRC)
[6] Kantha Bopha Children’s Hospital,undefined
[7] University Children’s Hospital of Zurich,undefined
[8] University Children’s Hospital of Zurich,undefined
来源：
European Journal of Pediatrics | 2011年 / 170卷
关键词：
Cerebral lesions; Diagnosis; Magnetic resonance imaging; H-magnetic resonance spectroscopy; Toddler; Tuberculosis;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Toddlers are more prone to develop severe and extrapulmonary tuberculosis (TB) than older children. This is partially explained by differences in the immune response. Early and specific diagnosis is essential to start adequate treatment, especially if the central nervous system (CNS) is involved. The lack of sputum production and inherent dangers or impossibility of sampling CNS lesions may delay diagnosis. In addition, the magnetic resonance imaging (MRI) features of TB abscesses are non-specific and may mimic abscesses of other infectious etiology. 1H-magnetic resonance spectroscopy (1H-MRS) may increase specificity of diagnosis by identifying lipids within the lesions that are considered characteristic for TB. Therefore, we studied four children with presumable CNS-TB with MRI and 1H-MRS. In vivo and in vitro 1H-MRS showed elevated lipid peaks within the TB lesions. Conclusion:1H-MRS allows to non-invasively identifying TB with high specificity and may allow early installment of targeted antimicrobial treatment.
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页码：379 / 387
页数：8
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