Autoantibodies and other serological markers in rheumatoid arthritis: predictors of disease activity?

被引：0
作者：
Licia Maria Henrique da Mota
Leopoldo Luiz dos Santos Neto
Jozélio Freire de Carvalho
机构：
[1] Brasília University Hospital,Department of Rheumatology
[2] University of São Paulo School of Medicine,Department of Rheumatology
[3] Disciplina de Reumatologia da FMUSP,undefined
来源：
Clinical Rheumatology | 2009年 / 28卷
关键词：
Autoantibodies; Disease activity; Rheumatoid arthritis; Serological markers;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The description of potential serological markers of rheumatoid arthritis (RA) activity can be quite useful in optimizing RA treatment, since the laboratory markers currently used, namely erythrocyte sedimentation rate and C-reactive protein, are not specific for RA and are influenced by several other variables. The markers proposed for assessing RA activity include rheumatoid factor, anti-citrullinated protein/peptide antibodies, immunoglobulin M (IgM) anti-IgG advanced glycation end products, markers of bone/cartilage metabolism, mannose-binding lectin, E-selectin, interleukin-6, and leptin. Various studies have investigated the correlation between some of these markers and other variables that might indicate disease activity, e.g., inflammatory activity tests and disease activity scores. However, there is as yet insufficient evidence that any of these markers, in isolation or in combination, are useful in the assessment of RA activity.
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页码：1127 / 1134
页数：7
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