Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9

被引：0
作者：
Umeharu Ohto
Takuma Shibata
Hiromi Tanji
Hanako Ishida
Elena Krayukhina
Susumu Uchiyama
Kensuke Miyake
Toshiyuki Shimizu
机构：
[1] Graduate School of Pharmaceutical Sciences,Division of Innate Immunity, Department of Microbiology and Immunology
[2] The University of Tokyo,undefined
[3] Hongo,undefined
[4] Bunkyo-ku,undefined
[5] Tokyo 113-0033,undefined
[6] Japan,undefined
[7] Laboratory of Innate Immunity,undefined
[8] Center for Experimental Medicine and Systems Biology,undefined
[9] The Institute of Medical Science,undefined
[10] The University of Tokyo,undefined
[11] 4-6-1 Shirokanedai,undefined
[12] Minato-ku,undefined
[13] Tokyo 108-8639,undefined
[14] Japan,undefined
[15] Core Research for Evolutional Science and Technology (CREST),undefined
[16] Japan Science and Technology Agency (JST),undefined
[17] Saitama 332-0012,undefined
[18] Japan,undefined
[19] Graduate School of Engineering,undefined
[20] Osaka University,undefined
[21] 2-1 Yamadaoka,undefined
[22] Suita,undefined
[23] Osaka 565-0871,undefined
[24] Japan,undefined
[25] U-Medico Corporation,undefined
[26] 2-1 Yamadaoka,undefined
[27] Suita,undefined
[28] Osaka 565-0871,undefined
[29] Japan,undefined
来源：
Nature | 2015年 / 520卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Crystal structures of three forms of Toll-like receptor (TLR) 9 — unliganded or bound either to immune stimulatory CpG-containing DNA or inhibitory DNA — together reveal the molecular basis of TLR9 activation.
引用
收藏
页码：702 / 705
页数：3
相关论文
共 70 条
[1]  
Janeway CA(2002)Innate immune recognition Annu. Rev. Immunol. 20 197-216
[2]  
Medzhitov R(2004)Toll-like receptor signalling Nature Rev. Immunol. 4 499-511
[3]  
Akira S(2001)Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition Proc. Natl Acad. Sci. USA 98 9237-9242
[4]  
Takeda K(2000)A Toll-like receptor recognizes bacterial DNA Nature 408 740-745
[5]  
Bauer S(1995)CpG motifs in bacterial DNA trigger direct B-cell activation Nature 374 546-549
[6]  
Hemmi H(2011)Nucleic acid recognition by Toll-like receptors is coupled to stepwise processing by cathepsins and asparagine endopeptidase J. Exp. Med. 208 643-651
[7]  
Krieg AM(2009)Critical role for asparagine endopeptidase in endocytic Toll-like receptor signaling in dendritic cells Immunity 31 737-748
[8]  
Ewald SE(2008)Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9 Nature Immunol. 9 1407-1414
[9]  
Sepulveda FE(2008)The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor Nature 456 658-662
[10]  
Park B(2013)An essential role for the N-terminal fragment of Toll-like receptor 9 in DNA sensing Nature Commun. 4 1949-1082
1234567