Seborrheic keratosis with Bowenoid transformation

被引：0

作者：

Beheshti A. ^{[1
]}

Hajmanoochehri F. ^{[1
]}

机构：

[1] Bouali-Hospital, Medical School, Qazvin University of Medical Sciences, Qazvin

来源：

Comparative Clinical Pathology | 2015年 / 24卷 / 3期

关键词：

Bowenoid transformation; Seborrheic keratosis;

D O I：

10.1007/s00580-014-2042-3

中图分类号：

学科分类号：

摘要：

Seborrheic keratosis is a benign epidermal tumor but may transform to malignant lesion in sun-exposed areas of the skin. In current study, we report here a patient who presented with multiple cutaneous horns originating from seborrheic keratosis with Bowenoid transformation on the back of the shoulder as an uncommon site. An 88-year-old Iranian woman presented with a multi-conical keratotic projection lesion (7 × 8 cm) on the back of the left shoulder. A biopsy of the lesion revealed intra-epidermal neoplasm that is composed of acanthosis, hyperkeratosis, and parakeratosis. Total thickness of epidermis is composed of atypical squamous cells with foci of individual keratinization, anaplastic cells, and frequent mitosis. Based on the clinical and pathologic findings, we diagnosed this lesion as a cutaneous horn originating from seborrheic keratosis with Bowenoid transformation. Histopathologic examination of all seborrheic keratosis cases should be considered, especially when seborrheic keratosis has atypical clinical manifestations. © 2015, Springer-Verlag London.

引用

页码：703 / 704

页数：1

共 10 条

[1]

Bai H., Cviko A., Granter S., Yuan L., Betensky R.A., Crum C.P., Immunophenotypic and viral (human papillomavirus) correlates of vulvar seborrheic keratosis, Hum Pathol, 34, pp. 559-564, (2003)

[2]

Cascajo C.D., Reichel M., Sanchez J.L., Malignant neoplasms associated with seborrheic keratosis. An analysis of 54 cases, Am J Dermatopathol, 18, pp. 278-282, (1996)

[3]

Cockerell C.J., Larsen F., Benign epithelial tumors and proliferation, Dermatology, pp. 1675-1676, (2003)

[4]

Hafner C., van Oers J.M., Hartmann A., Landthaler M., Stoehr R., Blaszyk H., Et al., High frequency of FGFR3 mutations in adenoid seborrheic keratosis, J Invest Dermatol, 126, pp. 2404-2407, (2006)

[5]

Kennedy C., Bajdik C.D., Willemze R., De Gruijl F.R., BouwesBavinck J.N., The influence of painful sunburns and lifetime sun exposure on the risk of actinic keratosis, seborrheic warts, melanocytic nevi, atypical nevi, and skin cancer, J Invest Dermatol, 120, pp. 1087-1093, (2003)

[6]

Kirkham N., Lever histopathology of the skin. 9th ed. Delhi, (distributed by Jaypee brothers): Lippincott Williams and Wilkins. Tumours and cysts of the epidermis

[7]

pp, 809–12, (2005)

[8]

Lim C., Seborrhoeic keratosis with associated lesions: a retrospective analysis of 85 lesions, Australas J Dermatol, 47, pp. 109-113, (2006)

[9]

Rongioletti F., Corbella L., Rebora A., Multiple familial seborrheic keratosis, Dermatologica, 176, pp. 43-45, (1988)

[10]

Yeatman J.M., Kilkenny M., Marks R., The prevalence of seborrheic kerasotes in an Australian population: does exposure to sunlight play a part in their frequency?, Br J Dermatol, 137, pp. 411-414, (1997)

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