Synthesis of 1,3-benzothiazines by intramolecular dehydrogenative C–S cross-coupling in a flow electrolysis cell

被引：0
|
作者：
Chong Huang
Hai-Chao Xu
机构：
[1] Xiamen University,State Key Laboratory of Physical Chemistry of Solid Surfaces, Innovative Collaboration Center of Chemistry for Energy Materials, Key Laboratory of Chemical Biology of Fujian Province, College of Chemistry and Chemical Engineering
来源：
Science China Chemistry | 2019年 / 62卷
关键词：
C-H functionalization; electrochemistry; flow chemistry; heterocycles;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Dehydrogenative cyclization of thioamides is an attractive approach for the synthesis of S-heterocycles. Reported herein is an electrochemical dehydrogenative cyclization reaction of N-benzyl thioamides in a flow electrolysis cell. The continuous-flow electrosynthesis has addressed the limitations associated with previously reported methods for the cyclization of alkylthioamides and provide a transition metal- and oxidizing reagent-free access to various functionalized 1,3-benzothiazines in good yields.
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页码：1501 / 1503
页数：2
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