Effects of Estrogen on the Gastrointestinal Tract

被引：0
作者：
Xubiao Nie
Rui Xie
Biguang Tuo
机构：
[1] Zunyi Medical College,Department of Gastroenterology, Affiliated Hospital
来源：
Digestive Diseases and Sciences | 2018年 / 63卷
关键词：
Estrogen; Estrogen receptors; Mucosal barrier; Intestinal inflammation; Gastrointestinal tumors;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Estrogen is a kind of steroid compound that has extensive biologic activities. The effect of estrogen is pleiotropic, affecting multiple systems in the body. There is accumulating evidence that estrogen has important effects on the gastrointestinal tract. Longer exposure to estrogen may decrease the risk of gastric cancer. Use of the anti-estrogen drug tamoxifen might increase the risk of gastric adenocarcinoma. Estrogen receptor β may serve as a target for colorectal cancer prevention. In addition, estrogen has been reported to be closely related to the mucosal barrier, gastrointestinal function and intestinal inflammation. However, the role of estrogen in the gastrointestinal tract has not been systematically summarized. In this review, we aim to provide an overview of the role of estrogen in the gastrointestinal tract and evaluate it from various aspects, including estrogen receptors, the mucosal barrier, intestinal inflammation and gastrointestinal tract tumors, which may provide the basis for the development of therapeutic strategies to manage gastrointestinal diseases.
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页码：583 / 596
页数：13
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