Big Bang and context-driven collapse

被引：0
作者：
Mark Robertson-Tessi
Alexander R A Anderson
机构：
[1] H. Lee Moffitt Cancer Center and Research Institute,Mark Robertson
[2] Tampa,Tessi and Alexander R. A. Anderson are in the Integrated Mathematical Oncology Department
[3] Florida,undefined
[4] USA.,undefined
来源：
Nature Genetics | 2015年 / 47卷
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摘要：
Heterogeneity is the single most important factor driving cancer progression and treatment failure, yet little is understood about how and when this heterogeneity arises. A new study shows that colorectal cancers acquire their dominant mutations early in development and that subsequent mutations, even if they confer greater fitness, are unlikely to sweep through the tumor.
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页码：196 / 197
页数：1
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