Big Bang and context-driven collapse

被引：0
作者：
Mark Robertson-Tessi
Alexander R A Anderson
机构：
[1] H. Lee Moffitt Cancer Center and Research Institute,Mark Robertson
[2] Tampa,Tessi and Alexander R. A. Anderson are in the Integrated Mathematical Oncology Department
[3] Florida,undefined
[4] USA.,undefined
来源：
Nature Genetics | 2015年 / 47卷
关键词：
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Heterogeneity is the single most important factor driving cancer progression and treatment failure, yet little is understood about how and when this heterogeneity arises. A new study shows that colorectal cancers acquire their dominant mutations early in development and that subsequent mutations, even if they confer greater fitness, are unlikely to sweep through the tumor.
引用
收藏
页码：196 / 197
页数：1
相关论文
共 31 条
[1]  
Marusyk A(2012)undefined Nat. Rev. Cancer 12 323-334
[2]  
Almendro V(2012)undefined N. Engl. J. Med. 366 883-892
[3]  
Polyak K(2008)undefined Nat. Rev. Cancer 8 227-234
[4]  
Gerlinger M(2015)undefined Nat. Genet. 47 209-216
[5]  
Anderson ARA(1976)undefined Science 194 23-28
[6]  
Quaranta V(2006)undefined Nat. Rev. Cancer 6 924-935
[7]  
Sottoriva A(2008)undefined Transl. Oncol. 1 158-164
[8]  
Nowell PC(2013)undefined Interface Focus 3 20130020-566
[9]  
Merlo LMF(2010)undefined Phil. Trans. Royal Soc. B 365 557-238
[10]  
Pepper JW(2011)undefined Nat. Rev. Cancer 11 237-440
1234