Neuroprotection in Multiple Sclerosis: A Therapeutic Approach

被引：0
作者：
Amir-Hadi Maghzi
Alireza Minagar
Emmanuelle Waubant
机构：
[1] University of California San Francisco (UCSF),Multiple Sclerosis Center, Department of Neurology
[2] Louisiana State University Health Sciences Center,Department of Neurology
来源：
CNS Drugs | 2013年 / 27卷
关键词：
Multiple Sclerosis; Experimental Autoimmune Encephalomyelitis; Pioglitazone; Retinal Nerve Fiber Layer; Retinal Nerve Fiber Layer Thickness;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Multiple sclerosis (MS) is a demyelinating disease of the central nervous system that is pathologically characterized by inflammatory demyelination and neurodegeneration. Axonal damage, along with neuronal loss, occurs from disease onset and may lead to progressive and permanent disability. In contrast with the inflammatory pathways, the molecular mechanisms leading to MS neurodegeneration remain largely elusive. With improved understanding of these mechanisms, new potential therapeutic targets for neuroprotection have emerged. We review the current understanding of neurodegenerative processes at play in MS and discuss potential outcome measures and targets for neuroprotection trials.
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页码：799 / 815
页数：16
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