Role of JAK1, JAK2, and JAK3 in Functional Stimulation of Mesenchymal Precursor Cells by Alkaloid Songorine

被引：0
作者：
G. N. Zyuz’kov
E. V. Udut
L. A. Miroshnichenko
E. V. Simanina
T. Yu. Polyakova
L. A. Stavrova
V. V. Udut
M. Yu. Minakova
A. M. Dygai
A. V. Chaikovskii
V. I. Agafonov
V. V. Zhdanov
机构：
[1] E. D. Goldberg Research Institute of Pharmacology and Regenerative Medicine,Laboratory of Modeling of Physical Processes in Biology and Medicine
[2] National Research Tomsk State University,undefined
来源：
Bulletin of Experimental Biology and Medicine | 2017年 / 163卷
关键词：
signal transduction; JAK; stem cells; regenerative medicine; alkaloids;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
We studied the role of some JAK in the effect of diterpene alkaloid songorine on realization of the growth potential of mesenchymal precursor cells. The participation of JAK1, JAK2, and JAK3 in stimulation of proliferation of the precursor cells was demonstrated. Specific inhibitors of these JAK reduced the yield of fibroblast CFU and the rate of their division. Inhibition of JAK2 against the background of songorine treatment increased the rate of precursor differentiation.
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页码：443 / 446
页数：3
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