Spaceflight associated neuro-ocular syndrome (SANS) and the neuro-ophthalmologic effects of microgravity: a review and an update

被引：222

作者：

Lee, Andrew G. ^{[1
,2
,3
,4
,5
,6
,7
,8
,9
]}

Mader, Thomas H. ^{[10
]}

Gibson, C. Robert ^{[11
]}

Tarver, William ^{[12
]}

Rabiei, Pejman ^{[13
]}

Riascos, Roy F. ^{[13
]}

Galdamez, Laura A. ^{[14
]}

Brunstetter, Tyson ^{[15
]}

机构：

[1] Houston Methodist Hosp, Dept Ophthalmol, Houston, TX 77030 USA

[2] Baylor Coll Med, Houston, TX 77030 USA

[3] Baylor Ctr Space Med, Houston, TX 77030 USA

[4] Weill Cornell Med Coll, Dept Ophthalmol, New York, NY 10065 USA

[5] Weill Cornell Med Coll, Dept Neurol, New York, NY 10065 USA

[6] Weill Cornell Med Coll, Dept Neurosurg, New York, NY 10065 USA

[7] Univ Texas Med Branch, Dept Ophthalmol, Galveston, TX 77555 USA

[8] Univ Iowa Hosp & Clin, Dept Ophthalmol, Iowa City, IA 52242 USA

[9] UT MD Anderson Canc Ctr, Houston, TX 77030 USA

[10] US Army, Moab, UT USA

[11] Coastal Eye Associates, Webster, TX USA

[12] NASA, Space Flight Associated Neuroocular Syndrome SANS, Clin Serv, Johnson Space Ctr, Houston, TX USA

[13] Univ Texas Hlth Sci Ctr Houston, Dept Diagnost & Intervent Imaging, Houston, TX 77030 USA

[14] NASA, US Navy, Johnson Space Ctr, Houston, TX USA

[15] Baylor Coll Med, Dept Emergency Med, Houston, TX 77030 USA

来源：

NPJ MICROGRAVITY | 2020年 / 6卷 / 01期

关键词：

HEAD-DOWN-TILT; IDIOPATHIC INTRACRANIAL HYPERTENSION; OPTIC DISC EDEMA; DIRECTIONAL GLYMPHATIC FLOW; ONE-WAY TICKET; INTRAOCULAR-PRESSURE; VISUAL IMPAIRMENT; CARBON-DIOXIDE; BED REST; ASYMMETRIC PAPILLEDEMA;

D O I：

10.1038/s41526-020-0097-9

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Prolonged microgravity exposure during long-duration spaceflight (LDSF) produces unusual physiologic and pathologic neuro-ophthalmic findings in astronauts. These microgravity associated findings collectively define the "Spaceflight Associated Neuro-ocular Syndrome" (SANS). We compare and contrast prior published work on SANS by the National Aeronautics and Space Administration's (NASA) Space Medicine Operations Division with retrospective and prospective studies from other research groups. In this manuscript, we update and review the clinical manifestations of SANS including: unilateral and bilateral optic disc edema, globe flattening, choroidal and retinal folds, hyperopic refractive error shifts, and focal areas of ischemic retina (i.e., cotton wool spots). We also discuss the knowledge gaps for in-flight and terrestrial human research including potential countermeasures for future study. We recommend that NASA and its research partners continue to study SANS in preparation for future longer duration manned space missions.

引用

页数：10

共 86 条

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