Tissue-Specific Expression of Splice Variants of Human IL-4 and IL-6 Gene mRNA

被引：0
作者：
O. P. Yatsenko
A. N. Silkov
E. A. Khrapov
M. L. Filipenko
V. A. Kozlov
S. V. Sennikov
机构：
[1] Siberian Division of Russian Academy of Medical Sciences,Research Institute of Clinical Immunology
[2] Siberian Division of the Russian Academy of Sciences,Institute of Chemical Biology and Fundamental Medicine
来源：
Bulletin of Experimental Biology and Medicine | 2012年 / 152卷
关键词：
cytokines; alternative splicing; tissue specificity;
D O I：
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中图分类号：
学科分类号：
摘要：
The spectrum of alternatively spliced IL-4 and IL-6 gene mRNA was studied in peripheral blood mononuclears from healthy donors and in human fetal tissues. It was found that the expression of alternatively spliced IL-4 and IL-6 gene mRNA in fetal tissues is tissue specific and that hemopoiesis- and immunopoiesis-related tissues differ by the amount of IL-4 and IL-4δ2 mRNA. An mRNA variant IL-4alt3 carrying partial exon 3 deletion was for the first time identified in human mononuclear cells.
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页码：329 / 332
页数：3
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