The Stimulation of Vertebral and Tibial Bone Growth by the Parathyroid Hormone Fragments, hPTH-(1-31)NH2, [Leu27]cyclo(Glu22-Lys26)hPTH-(1-31)NH2, and hPTH-(1-30)NH2

被引：0

作者：

J. F. Whitfield

P. Morley

L. Fraher

A. B. Hodsman

D. W. Holdsworth

P. H. Watson

G. E. Willick

J.-R. Barbier

M. Gulam

R. J. Isaacs

S. MacLean

V. Ross

机构：

[1] Institute for Biological Sciences,

[2] National Research Council of Canada,undefined

[3] Building M-54,undefined

[4] Montreal Road Campus,undefined

[5] Ottawa,undefined

[6] Ontario,undefined

[7] Canada K1A OR6,undefined

[8] Department of Medicine,undefined

[9] Lawson Research Institute,undefined

[10] University of Western Ontario,undefined

[11] St. Joseph's Health Center,undefined

[12] 268 Grosvenor Street,undefined

[13] London,undefined

[14] Ontario,undefined

[15] Canada N6A 4V2,undefined

[16] Imaging Research Labs,undefined

[17] Robarts Research Institute,undefined

[18] 100 Perth Drive,undefined

[19] University of Western Ontario,undefined

[20] London,undefined

[21] Ontario,undefined

[22] Canada N6A 5K,undefined

来源：

Calcified Tissue International | 2000年 / 66卷

关键词：

Key words: Bone mineral density — Osteoporosis — Parathyroid hormone analogs — Pelvis — Tibia — Trabecular bone — Vertebrae.;

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中图分类号：

学科分类号：

摘要：

The native human parathyroid hormone, hPTH-(1-84), and certain carboxyl truncated analogs such as hPTH-(1-34) and even smaller fragments such as hPTH-(1-31)NH2, [Leu27]cyclo(Glu22-Lys26)hPTH-(1-31)NH2, and hPTH-(1-30)NH2 stimulate femoral trabecular and cortical bone growth in ovariectomized (OVX) rats. Here we show that when injected once daily for 6 weeks starting 2 weeks after OVX in doses of 1 or 2 nmol/100 g of body weight, hPTH-(1-31)NH2, [Leu27]cyclo(Glu22-Lys26)hPTH-(1-31)NH2, and hPTH-(1-34)NH2 prevented the loss of trabecular volume in the L5 vertebrae induced by OVX. In fact, by the end of the sixth week of injections (i.e., the eighth week after OVX) the fragments had increased the volume and trabecular thickness significantly above the values in vehicle-injected sham-operated rats. hPTH-(1-30)NH2 can stimulate vertebral bone growth as much as the larger fragments, but 10–25 times more of it was needed to do so. The same daily doses of hPTH-(1-31)NH2, [Leu27]cyclo(Glu22-Lys26)hPTH-(1-31)NH2, and hPTH-(1-34)NH2 also raised the trabecular volume and thickness in the L5 vertebrae of rats well above the values in vehicle-treated animals when the injections were started 9 weeks after OVX. This restoration of trabecular bone in the L5 vertebrae in estrogen-deprived animals was accompanied by a significant increase in the bone mineral density (BMD) of the L1–L4 vertebrae and tibias. However, there was no significant drop in the pelvic BMD in the estrogen-deprived animals and the effects of hPTH-(1-31)NH2, [Leu27]cyclo(Glu22-(Lys) hPTH-(1-31)NH2, and hPTH-(1-34)NH2 on the pelvic BMD were equivocal.

引用

页码：307 / 312

页数：5