Rescuing drug discovery: in vivo systems pathology and systems pharmacology

被引：0
作者：
Jan van der Greef
Robert N. McBurney
机构：
[1] TNO Systems Biology,
[2] Netherlands Organization for Applied Scientific Research,undefined
[3] Utrechtseweg 48,undefined
[4] PO BOX 360,undefined
[5] Centre for Medical Systems Biology/Leiden Amsterdam Centre for Drug Research,undefined
[6] Einsteinweg 55,undefined
[7] PO BOX 9502,undefined
[8] BG Medicine,undefined
[9] Inc.,undefined
[10] BG Medicine,undefined
[11] Inc.,undefined
来源：
Nature Reviews Drug Discovery | 2005年 / 4卷
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D O I：
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学科分类号：
摘要：
The pharmaceutical industry is currently beleaguered by close scrutiny from the financial community, regulators and the general public. Productivity, in terms of new drug approvals, has generally been falling for almost a decade and the safety of a number of highly successful drugs has recently been brought into question. Here, we discuss whether taking an in vivo systems approach to drug discovery and development could be the paradigm shift that rescues the industry.
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页码：961 / 967
页数：6
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