Midbrain dopaminergic neuron fate specification: Of mice and embryonic stem cells

被引：0
作者：
Emily Gale
Meng Li
机构：
[1] Imperial College London,MRC Clinical Sciences Centre
来源：
Molecular Brain | / 1卷
关键词：
Embryonic Stem Cell; Neural Stem Cell; Neural Progenitor; Mouse Embryonic Stem Cell; Neural Plate;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The midbrain dopaminergic (mDA) neurons of the substantia nigra and the ventral tegmental area play a fundamental role in the control of voluntary movement and the regulation of emotion, and are severely affected in Parkinson's disease. Recent advances in mouse genetics and vertebrate development have provided us with insight into the genetic cascades involved in the development of mDA neurons, including the induction of mDA neuron progenitors in the ventral mesencephalon, the specification of the mDA neuronal fate and the maintenance of postmitotic mDA neurons. In parallel, rapid progress has been made in the generation of DA neurons from pluripotent stem cells and the development of stem cell-based therapies for Parkinson's disease. Here, we summarize the new findings via the developmental progression of mDA neurons and outline how this knowledge has been exploited to develop novel paradigms for the in vitro generation of these neurons from embryonic stem cells.
引用
收藏
相关论文
共 567 条
  • [1] Bjorklund A(1984)Dopamine-containing systems in the CNS Handbook of Chemical Neuroanatomy 2 55-113
  • [2] Lindvall O(2006)Development of dopaminergic neurons in the mammalian brain Cell Mol Life Sci 63 187-206
  • [3] Prakash N(2006)A Wnt1-regulated genetic network controls the identity and fate of midbrain-dopaminergic progenitors in vivo Development 133 89-98
  • [4] Wurst W(2006)Transcriptional control of midbrain dopaminergic neuron development Development 133 3499-3506
  • [5] Prakash N(2007)How to make a mesodiencephalic dopaminergic neuron Nat Rev Neurosci 8 21-32
  • [6] Brodski C(2003)Transcriptional control of dopamine neuron development Ann N Y Acad Sci 991 48-60
  • [7] Naserke T(2003)Midbrain dopaminergic neurons: determination of their developmental fate by transcription factors Ann N Y Acad Sci 991 36-47
  • [8] Puelles E(2001)Regionalisation of anterior neuroectoderm and its competence in responding to forebrain and midbrain inducing activities depend on mutual antagonism between OTX2 and GBX2 Development 128 4789-4800
  • [9] Gogoi R(2001)Otx2 and Gbx2 are required for refinement and not induction of mid-hindbrain gene expression Development 128 4979-4991
  • [10] Hall A(2005)Isthmus organizer and regionalization of the mesencephalon and metencephalon Int J Dev Biol 49 231-235
12345678910