The beneficial effects of intracoronary autologous bone marrow stem cell transfer as an adjunct to percutaneous coronary intervention in patients with acute myocardial infarction

被引：0
作者：
Xiang Wang
Wei-chun Xi
Fang Wang
机构：
[1] Affiliated Shanghai Jiaotong University,Department of Cardiology, Shanghai First People’s Hospital
来源：
Biotechnology Letters | 2014年 / 36卷
关键词：
Acute myocardial infarction; Bone marrow mesenchymal stem cell; Cell transplantation; Percutaneous coronary intervention;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
The efficacy of post-percutaneous coronary intervention (PCI) intracoronary injection with bone marrow mesenchymal stem cells (BMSCs) in patients with acute myocardial infarction (AMI) remains controversial. Here, 58 patients with AMI undergoing PCI were randomly divided into two groups: BMSC and control groups. Autologous BSMCs were then generated in vitro from the BMSC patients. After transplantation, left ventricular ejection fraction (LVEF), left ventricular end-diastolic dimensions (LVDd), and infarct size (IS) were evaluated in both groups. LVEF, LVDd, and IS improved after BMSC transplantation but the changes were not significantly different from those in the controls. The number of adverse events and rehospitalization rates after 1 month were significantly higher in the control group than in the BMSC group. BMSC transplantation thus benefits patients by decreasing the number of adverse events and reducing the rehospitalization rate in the early stages following PCI.
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页码：2163 / 2168
页数：5
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