Evaluation of lipid-lowering effect of Cynara scolymus extract-loaded mesoporous silica nanoparticles on ultra-lipid-fed mice

被引：1

作者：

Safat A.A. ^{[1
]}

Sheibani H. ^{[2
]}

Mohammadi P. ^{[2
]}

Hasanabadi N. ^{[1
]}

Sakhaee E. ^{[1
]}

机构：

[1] Department of Clinical Sciences, School of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman

[2] Department of Chemistry, Shahid Bahonar University of Kerman, Kerman

来源：

Comparative Clinical Pathology | 2018年 / 27卷 / 2期

关键词：

Cynara scolymus extract; Mice; Nanoparticles; Serum lipids;

D O I：

10.1007/s00580-017-2621-1

中图分类号：

学科分类号：

摘要：

In current investigation, twenty mice were divided into 4 different equal groups as follows: group CS which received 0.1 ml Cynara scolymus extract (diluted in distilled water) at dose of 600 mg kg−1 daily for 3 weeks, group A which received 0.1 ml Atorvastatin 40 (diluted in distilled water) at dose of 20 mg kg−1 daily for 21 days, group T which received 0.1 ml of Cynara scolymus extract at dose of 600 mg kg−1 daily in nonporous (diluted in distilled water) during experimental period, and control group (group C) which received the same volume of normal saline. The supplements were gavaged in all animals, during experiment period, and blood samples were obtained after 21 days. Results showed that total cholesterol and triglyceride decreased significantly in the treatment group compared with the control and CS groups (p OpenSPiltSPi 0.05). It seems that mesoporous silica nanoparticles improve drug delivery and therefore Cynara scolymus extract-loaded mesoporous silica nanoparticles has more effective lipid-lowering action than Cynara scolymus extract. © 2017, Springer-Verlag London Ltd., part of Springer Nature.

引用

页码：513 / 518

页数：5