Citrullination regulates pluripotency and histone H1 binding to chromatin

被引：0

作者：

Maria A. Christophorou

Gonçalo Castelo-Branco

Richard P. Halley-Stott

Clara Slade Oliveira

Remco Loos

Aliaksandra Radzisheuskaya

Kerri A. Mowen

Paul Bertone

José C. R. Silva

Magdalena Zernicka-Goetz

Michael L. Nielsen

John B. Gurdon

Tony Kouzarides

机构：

[1] The Gurdon Institute,Department of Medical Biochemistry and Biophysics

[2] University of Cambridge,Department of Zoology

[3] Tennis Court Road,Department of Physiology

[4] Cambridge CB2 1QN,Department of Biochemistry

[5] UK,Department of Chemical Physiology

[6] Laboratory of Molecular Neurobiology,Department of proteomics

[7] Karolinska Institutet,Department of Pathology

[8] SE-17177 Stockholm,undefined

[9] Sweden,undefined

[10] University of Cambridge,undefined

[11] Downing Street,undefined

[12] Cambridge CB2 3EJ,undefined

[13] UK,undefined

[14] EMBRAPA Dairy Cattle Research Center,undefined

[15] Juiz de Fora,undefined

[16] Brazil,undefined

[17] Development and Neuroscience,undefined

[18] University of Cambridge,undefined

[19] Tennis Court Road,undefined

[20] Cambridge CB2 1QN,undefined

[21] UK,undefined

[22] European Molecular Biology Laboratory,undefined

[23] European Bioinformatics Institute,undefined

[24] Wellcome Trust Genome Campus,undefined

[25] Cambridge CB10 1SD,undefined

[26] UK,undefined

[27] Wellcome Trust—Medical Research Council Cambridge Stem Cell Institute,undefined

[28] University of Cambridge,undefined

[29] Tennis Court Road,undefined

[30] Cambridge CB2 1QR,undefined

[31] UK,undefined

[32] University of Cambridge,undefined

[33] Tennis Court Road,undefined

[34] Cambridge CB2 1QR,undefined

[35] UK,undefined

[36] The Scripps Research Institute,undefined

[37] Genome Biology and Developmental Biology Units,undefined

[38] European Molecular Biology Laboratory,undefined

[39] Meyerhofstraße 1,undefined

[40] 69117 Heidelberg,undefined

[41] Germany,undefined

[42] The Novo Nordisk Foundation Center for Protein Research,undefined

[43] University of Copenhagen,undefined

[44] Faculty of Health Sciences,undefined

[45] Blegdamsvej 3b,undefined

[46] DK-2200 Copenhagen,undefined

[47] Denmark,undefined

[48] University of Cambridge,undefined

[49] Tennis Court Road,undefined

[50] Cambridge CB2 1QN,undefined

来源：

Nature | 2014年 / 507卷

关键词：

D O I：

暂无

中图分类号：

学科分类号：

摘要：

This study shows that PADI4-mediated citrullination occurs during pluripotency and that citrullination of H1 results in loosening of chromatin compaction; furthermore, citrullination is shown to be important for the activation of stem-cell genes, for iPS cell reprogramming and to maintain pluripotent cells in the early mouse embryo.

引用

页码：104 / 108

页数：4

共 50 条

[41] Histone H1 and chromatin higher-order structure
Ramakrishnan, V
CRITICAL REVIEWS IN EUKARYOTIC GENE EXPRESSION, 1997, 7 (03): : 215 - 230
[42] Effects of H1 histone variant overexpression on chromatin structure
Gunjan, A
Alexander, BT
Sittman, DB
Brown, DT
JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (53) : 37950 - 37956
[43] Chromatin structure: Linking structure to function with histone H1
Widom, J
CURRENT BIOLOGY, 1998, 8 (22) : R788 - R791
[44] EFFECT OF ORGANIC EFFECTORS ON CHROMATIN SOLUBILITY, DNA-HISTONE H1 INTERACTIONS, DNA AND HISTONE H1 STRUCTURES
BUCHE, A
COLSON, P
HOUSSIER, C
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 1993, 11 (01): : 95 - 119
[45] Histone H1 binding is inhibited by histone variant H3.3
Braunschweig, Ulrich
Hogan, Greg J.
Pagie, Ludo
van Steensel, Bas
EMBO JOURNAL, 2009, 28 (23): : 3635 - 3645
[46] Histone H1 acetylation at lysine 85 regulates chromatin condensation and genome stability upon DNA damage
Li, Yinglu
Li, Zhiming
Dong, Liping
Tang, Ming
Zhang, Ping
Zhang, Chaohua
Cao, Ziyang
Zhu, Qian
Chen, Yongcan
Wang, Hui
Wang, Tianzhuo
Lv, Danyu
Wang, Lina
Zhao, Ying
Yang, Yang
Wang, Haiying
Zhang, Hongquan
Roeder, Robert G.
Zhu, Wei-Guo
NUCLEIC ACIDS RESEARCH, 2018, 46 (15) : 7716 - 7730
[47] Phosphorylation of linker histone H1 regulates gene expression in vivo by mimicking H1 removal
Dou, YL
Mizzen, CA
Abrams, M
Allis, CD
Gorovsky, MA
MOLECULAR CELL, 1999, 4 (04) : 641 - 647
[48] HTLV-1 Tax transactivation on chromatin containing histone H1
Konesky, KL
Nyborg, JK
Laybourn, PJ
AIDS RESEARCH AND HUMAN RETROVIRUSES, 2003, 19 : S73 - S73
[49] INFLUENCE OF HISTONE H1 ON THE IN-VITRO REPLICATION OF DNA AND CHROMATIN
HALMER, L
GRUSS, C
NUCLEIC ACIDS RESEARCH, 1995, 23 (05) : 773 - 778
[50] CHROMATIN CONDENSATION - DOES HISTONE H1 DEPHOSPHORYLATION PLAY A ROLE
ROTH, SY
ALLIS, CD
TRENDS IN BIOCHEMICAL SCIENCES, 1992, 17 (03) : 93 - 98

← 1 2 3 4 5 →