Citrullination regulates pluripotency and histone H1 binding to chromatin

被引：0

作者：

Maria A. Christophorou

Gonçalo Castelo-Branco

Richard P. Halley-Stott

Clara Slade Oliveira

Remco Loos

Aliaksandra Radzisheuskaya

Kerri A. Mowen

Paul Bertone

José C. R. Silva

Magdalena Zernicka-Goetz

Michael L. Nielsen

John B. Gurdon

Tony Kouzarides

机构：

[1] The Gurdon Institute,Department of Medical Biochemistry and Biophysics

[2] University of Cambridge,Department of Zoology

[3] Tennis Court Road,Department of Physiology

[4] Cambridge CB2 1QN,Department of Biochemistry

[5] UK,Department of Chemical Physiology

[6] Laboratory of Molecular Neurobiology,Department of proteomics

[7] Karolinska Institutet,Department of Pathology

[8] SE-17177 Stockholm,undefined

[9] Sweden,undefined

[10] University of Cambridge,undefined

[11] Downing Street,undefined

[12] Cambridge CB2 3EJ,undefined

[13] UK,undefined

[14] EMBRAPA Dairy Cattle Research Center,undefined

[15] Juiz de Fora,undefined

[16] Brazil,undefined

[17] Development and Neuroscience,undefined

[18] University of Cambridge,undefined

[19] Tennis Court Road,undefined

[20] Cambridge CB2 1QN,undefined

[21] UK,undefined

[22] European Molecular Biology Laboratory,undefined

[23] European Bioinformatics Institute,undefined

[24] Wellcome Trust Genome Campus,undefined

[25] Cambridge CB10 1SD,undefined

[26] UK,undefined

[27] Wellcome Trust—Medical Research Council Cambridge Stem Cell Institute,undefined

[28] University of Cambridge,undefined

[29] Tennis Court Road,undefined

[30] Cambridge CB2 1QR,undefined

[31] UK,undefined

[32] University of Cambridge,undefined

[33] Tennis Court Road,undefined

[34] Cambridge CB2 1QR,undefined

[35] UK,undefined

[36] The Scripps Research Institute,undefined

[37] Genome Biology and Developmental Biology Units,undefined

[38] European Molecular Biology Laboratory,undefined

[39] Meyerhofstraße 1,undefined

[40] 69117 Heidelberg,undefined

[41] Germany,undefined

[42] The Novo Nordisk Foundation Center for Protein Research,undefined

[43] University of Copenhagen,undefined

[44] Faculty of Health Sciences,undefined

[45] Blegdamsvej 3b,undefined

[46] DK-2200 Copenhagen,undefined

[47] Denmark,undefined

[48] University of Cambridge,undefined

[49] Tennis Court Road,undefined

[50] Cambridge CB2 1QN,undefined

来源：

Nature | 2014年 / 507卷

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学科分类号：

摘要：

This study shows that PADI4-mediated citrullination occurs during pluripotency and that citrullination of H1 results in loosening of chromatin compaction; furthermore, citrullination is shown to be important for the activation of stem-cell genes, for iPS cell reprogramming and to maintain pluripotent cells in the early mouse embryo.

引用

页码：104 / 108

页数：4

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[1] Citrullination regulates pluripotency and histone H1 binding to chromatin
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