Desmosome–Ion Channel Interactions and Their Possible Role in Arrhythmogenic Cardiomyopathy

被引:1
作者
Mario Delmar
机构
[1] New York University School of Medicine,The Leon H. Charney Division of Cardiology
来源
Pediatric Cardiology | 2012年 / 33卷
关键词
Connexin; Desmosome; ARVC; Arrhythmogenic cardiomyopathy; Sodium channel;
D O I
暂无
中图分类号
学科分类号
摘要
Most commonly, arrhythmogenic cardiomyopathy (also known as arrhythmogenic right ventricular cardiomyopathy, or ARVC) is caused by mutations in desmosomal proteins. The question arises as to the mechanisms by which mutations in mechanical junctions, affect the rhythm of the heart. We have proposed that a component of the arrhythmogenic substrate may include changes in the function of both, gap junctions and sodium channels. Here, we review the relevant literature on this subject.
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页码:975 / 979
页数:4
相关论文
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