Rare deleterious mutations in Bruton’s tyrosine kinase as biomarkers for ibrutinib-based therapy: an in silico insight

Fania L(2021)Cutaneous squamous cell carcinoma: From pathophysiology to novel therapeutic approaches Biomedicines 9 1-33

GeidelG HI(2022)Emerging precision diagnostics in advanced cutaneous squamous cell carcinoma Npj Precision Oncology 6 1-8

Kött J(2008)‘The tumor microenvironment and its role in promoting tumor growth Oncogene 27 5904-13

Schneider SW(2004)‘A census of human cancer genes Nat Rev Cancer 4 177-219

Pantel K(2015)‘Targets for ibrutinib beyond B cell malignancies Scand J Immunol 82 208-25

Gebhardt C(2020)‘Inferring the molecular and phenotypic impact of amino acid variants with MutPred2 Nat Commun 11 1-413

Whiteside TL(2017)‘Ability of Bruton’s tyrosine kinase inhibitors to sequester Y551 and prevent phosphorylation determines potency for inhibition of Fc receptor but not B-cell receptor signaling Mol Pharmacol 91 208-583

Futreal PA(2015)‘GROMACS: High performance molecular simulations through multi-level parallelism from laptops to supercomputers SoftwareX 1–2 19-9508

Berglöf A(2017)‘CHARMM36m: An improved force field for folded and intrinsically disordered proteins Nat Methods 14 71-713

Pejaver V(2016)CHARMM-GUI input generator for NAMD, GROMACS, AMBER, OpenMM, and CHARMM/OpenMM simulations using the CHARMM36 additive force field J Chem Theory Comput 12 405-406

Fania L(2021)Cutaneous squamous cell carcinoma: From pathophysiology to novel therapeutic approaches Biomedicines 9 1-33

GeidelG HI(2022)Emerging precision diagnostics in advanced cutaneous squamous cell carcinoma Npj Precision Oncology 6 1-8

Kött J(2008)‘The tumor microenvironment and its role in promoting tumor growth Oncogene 27 5904-13

Schneider SW(2004)‘A census of human cancer genes Nat Rev Cancer 4 177-219

Pantel K(2015)‘Targets for ibrutinib beyond B cell malignancies Scand J Immunol 82 208-25

Gebhardt C(2020)‘Inferring the molecular and phenotypic impact of amino acid variants with MutPred2 Nat Commun 11 1-413

Whiteside TL(2017)‘Ability of Bruton’s tyrosine kinase inhibitors to sequester Y551 and prevent phosphorylation determines potency for inhibition of Fc receptor but not B-cell receptor signaling Mol Pharmacol 91 208-583

Futreal PA(2015)‘GROMACS: High performance molecular simulations through multi-level parallelism from laptops to supercomputers SoftwareX 1–2 19-9508

Berglöf A(2017)‘CHARMM36m: An improved force field for folded and intrinsically disordered proteins Nat Methods 14 71-713

Pejaver V(2016)CHARMM-GUI input generator for NAMD, GROMACS, AMBER, OpenMM, and CHARMM/OpenMM simulations using the CHARMM36 additive force field J Chem Theory Comput 12 405-406