Screening for oesophageal neoplasia in patients with head and neck cancer

被引：0

作者：

H Scherübl

B von Lampe

S Faiss

P Däubler

P Bohlmann

T Plath

H-D Foss

H Scherer

A Strunz

B Hoffmeister

H Stein

M Zeitz

E-O Riecken

机构：

[1] Medical Clinic I,ENT Department

[2] University Hospital Benjamin Franklin,Department of Maxillofacial Plastic Surgery

[3] Free University of Berlin,undefined

[4] University Hospital Benjamin Franklin,undefined

[5] Free University of Berlin,undefined

[6] University Hospital Benjamin Franklin,undefined

[7] Free University of Berlin,undefined

[8] Institute of Pathology,undefined

[9] University Hospital Benjamin Franklin,undefined

[10] Free University of Berlin,undefined

来源：

British Journal of Cancer | 2002年 / 86卷

关键词：

surveillance; secondary malignancy; squamous cell cancer; larynx; pharynx; oral cavity;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Due to advanced disease at the time of diagnosis the prognosis of oesophageal cancer is generally poor. As mass screening for oesophageal cancer is neither feasible nor reasonable, high-risk groups should be identified and surveilled. The aim of this study was to define the risk of oesophageal cancer in patients with (previous) head and neck cancer. A total of 148 patients with (previous) head and neck cancer were prospectively screened for oesophageal cancer by video-oesophagoscopy and random oesophageal biopsies. Even in a macroscopically normal looking oesophagus, four biopsy specimens were taken every 3 cm throughout the entire length of the squamous oesophagus. Low- or high-grade squamous cell dysplasia was detected histologically in 10 of the 148 patients (6.8%). All but one dysplasias were diagnosed synchronously with the head and neck cancers. In addition, oesophageal squamous cell carcinoma was diagnosed in 11 of the 148 patients (7.4%). Most invasive cancers (63.6%) occurred metachronously. The risk of squamous cell neoplasia of the oesophagus is high in patients with (previous) head and neck cancer. Surveillance is recommended in this high-risk group.

引用

页码：239 / 243

页数：4

共 225 条

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