Apolipoprotein E allele frequencies in argyrophilic grain disease

被引：0

作者：

Markus Tolnay

A. Probst

Andreas U. Monsch

Hannes B. Staehelin

Rupert Egensperger

机构：

[1] Institute of Pathology,

[2] Division of Neuropathology,undefined

[3] Schönbeinstrasse 40,undefined

[4] CH-4003 Basel,undefined

[5] Switzerland e-mail: aprobst@uhbs.ch,undefined

[6] Tel.: +41-61-265-2895,undefined

[7] Fax: +41-61-265-3194,undefined

[8] Geriatric University Clinic,undefined

[9] Hebelstrasse 10,undefined

[10] CH-4031 Basel,undefined

[11] Switzerland,undefined

[12] Institute of Neuropathology,undefined

[13] Hannover Medical School,undefined

[14] Carl-Neuberg-Strasse 1,undefined

[15] D-30625 Hannover,undefined

[16] Germany,undefined

来源：

Acta Neuropathologica | 1998年 / 96卷

关键词：

Key words Argyrophilic grain disease; Apolipoprotein E; Dementia;

D O I：

暂无

中图分类号：

学科分类号：

摘要：

Apolipoprotein E (ApoE) genotypes were analyzed in 35 subjects with argyrophilic grain disases (AgD). Neuropathologically, all cases were characterized by abundant argyrophilic grains in the hippocampus and in the entorhinal or parahippocampal cortex. We found an ApoE ɛ4 allele frequency of 0.007 in AgD patients, which is significantly different from the ɛ4 allele frequencies reported in age-matched Alzheimer’s disease (AD) patients (0.24), but not from age-matched controls (0.09). We conclude that the ApoE ɛ4 allele does not constitute a risk factor for the development of AgD. Our results further suggest that AgD is a progressive disorder differentiated from AD by morphological and genetic criteria.

引用

页码：225 / 227

页数：2