Risk factors for early progression of diffuse low-grade glioma in adults

被引：0

作者：

Wang L. ^{[1
]}

Li X. ^{[1
]}

Chen T. ^{[1
]}

Zhang C. ^{[1
]}

Shi J. ^{[1
]}

Feng H. ^{[1
]}

Li F. ^{[1
]}

机构：

[1] Department of Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing

来源：

Chinese Neurosurgical Journal | / 8卷 / 1期

基金：

中国国家自然科学基金;

关键词：

Early progression; Low-grade glioma; Risk factors;

D O I：

10.1186/s41016-022-00295-z

中图分类号：

学科分类号：

摘要：

Background: To explore the risk factors for early progression of diffuse low-grade glioma in adults. Methods: A retrospective analysis of pathologic and clinical data of patients diagnosed with diffuse low-grade gliomas at Southwest Hospital between January 2010 and December 2014. The progression-free survival (PFS) less than 60 months was classified as the early progress group, and the PFS greater than 60 months was the control group for comparative analysis. Results: A total of 138 patients were included in this study, including 94 cases of astrocytoma and 44 cases of oligodendroglioma. There were 63 cases with 100% resection, 56 cases with 90–100% resection degree, and 19 cases with resection degree < 90%. The average follow-up time was 60 months, of which 80 patients progressed and 58 patients did not progress. The average progression-free survival was 61 months. The median progression-free survival was 60 months. There were 68 patients with PFS≤ 60 months and 70 patients with PFS > 60 months. The two groups were compared for statistical analysis. In univariate analysis, there were significant differences in tumor subtype (p = 0.005), range (p = 0.011), volume (p = 0.005), location (p = 0.000), and extent of resection (p = 0.000). Multifactor analysis shows tumor location (HR = 4.549, 95% CI: 1.324–15.634, p = 0.016) and tumor subtype (HR = 3.347, 95% CI = 1.373–8.157, p = 0.008), and imcomplete resection is factors influencing early progression of low-grade glioma. Conclusions: Low-grade gliomas involving deep location such as basal ganglia, inner capsule, and corpus callosum are more likely to progress early, while incomplete resection is a risk factor in early progression of astrocytoma. © 2022, The Author(s).

引用

共 15 条

[1]

Louis D.N., Perry A., Wesseling P., Et al., The 2021 WHO classification of tumors of the central nervous system: a summary [J], Neuro-Oncology, 23, 8, pp. 1231-1251, (2021)

[2]

van den Bent M.J., Wefel J.S., Schiff D., Et al., Response assessment in neuro-oncology (a report of the RANO group): assessment of outcome in trials of diffuse low-grade gliomas, Lancet Oncol, 12, pp. 583-593, (2011)

[3]

Smits A., Jakola A.S., Clinical presentation, natural history, and prognosis of diffuse low-grade gliomas, Neurosurg Clin N Am, 30, 1, pp. 35-42, (2019)

[4]

Bready D., Placantonakis D.G., Molecular pathogenesis of low-grade glioma, Neurosurg Clin N Am, 30, pp. 17-25, (2019)

[5]

Duffau H., Taillandier L., New concepts in the management of diffuse low-grade glioma: proposal of a multistage and individualized therapeutic approach, Neuro-Oncology, 17, pp. 332-342, (2015)

[6]

Pignatti F., van den Bent M., Curran D., Et al., Prognostic factors for survival in adult patients with cerebral low-grade glioma, J Clin Oncol, 20, pp. 2076-2084, (2002)

[7]

Claus E.B., Black P.M., Survival rates and patterns of care for patients diagnosed with supratentorial low-grade gliomas: data from the SEER program, 1973-2001, Cancer, 106, pp. 1358-1363, (2006)

[8]

Soffietti R., Baumert B.G., Bello L., Et al., Guidelines on management of low-grade gliomas: report of an EFNS-EANO task force, Eur J Neurol, 17, pp. 1124-1133, (2010)

[9]

Ding X.J., Wang Z., Chen D., Et al., The prognostic value of maximal surgical resection is attenuated in oligodendroglioma subgroups of adult diffuse glioma: a multicenter retrospective study, J Neuro-Oncol, 140, pp. 591-603, (2018)

[10]

Shaw E.G., Berkey B., Coons S.W., Et al., Recurrence following neurosurgeon-determined gross-total resection of adult supratentorial low-grade glioma: results of a prospective clinical trial, J Neurosurg, 109, pp. 835-841, (2008)

← 1 2 →