Protective effect of secoisolariciresinol diglucoside against streptozotocin-induced diabetes and its mechanism

被引：7
作者：
Kailash Prasad
Subrahmanyam Mantha
Alister Muir
Neil Westcott
机构：
[1] University of Saskatchewan,Department of Physiology, College of Medicine
[2] Agriculture and Agri-Food Canada,undefined
来源：
Molecular and Cellular Biochemistry | 2000年 / 206卷
关键词：
oxygen free radicals; streptozotocin; diabetes; secoisolariciresinol diglucoside; malondialdehyde; pancreatic chemiluminescence;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Objectives: Reactive oxygen species (ROS) have been implicated in the development of streptozotocin (STZ)-induced diabetes mellitus. Secoisolariciresinol diglucoside (SDG) isolated from flaxseed is an antioxidant. An investigation was made of the effects of SDG on the development of STZ-induced diabetes in rat, to determine if SDG can prevent/reduce the development of diabetes and if this prevention/reduction is associated with reduction in oxidative stress.
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页码：141 / 150
页数：9
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