Predictive pathological factors of lymph nodes involvement in the squamous cell carcinoma of the penis

被引：34
作者：
Ficarra V. [1 ]
Martignoni G. [2 ]
Maffei N. [1 ]
Cerruto M.A. [1 ]
Novara G. [1 ]
Cavalleri S. [1 ]
Artibani W. [1 ]
机构：
[1] Department of Urology, University of Verona, Verona
[2] Department of Pathology, University of Verona, Verona
来源：
International Urology and Nephrology | 2002年 / 34卷 / 2期
关键词：
Histopathological features; Inguinal lymphadenectomy; Lymph nodes involvement; Penile squamous cell carcinoma;
D O I：
10.1023/A:1023243102230
中图分类号：
学科分类号：
摘要：
Objectives: To evaluate the predictive role of primary tumor histopathological features in predicting inguinal lymph nodes involvement in patients with penile squamous cell carcinoma. Material and methods: We retrospectively analysed pathological records from 30 consecutive patients who underwent penectomy for invasive squamous cell carcinoma of the penis. All histological specimens were reviewed by the same pathologist. We considered the following histological parameters: histological grading, growth pattern, deph invasion, tumour thickness, nuclear grading, poorly differentiated cancer rate, vascular and lymphatic embolization, eosinophilic and mononuclear infiltration and pathological stage. Results: Lymph nodes involvement occurred in 5 patients who underwent 'early' lymphadenectomy and in other 4 ones during oncological surveillance. Lymph nodes metastasis resulted significantly correlated with histological grading (p = 0.005), lymphatic (p = 0.005) and venous (p = 0.02) embolization, corpora cavernosa (p = 0.03) and urethra (p = 0.03) infiltration. Histological grading and lymphatic embolization were independent predictive variables of lymph nodes involvement (p = 0.02). Conclusions: The histological grading and lymphatic embolization have to be considered as important parameters to select patients with penile squamous cell carcinoma to undergo an 'early' lymphadenectomy.
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页码：245 / 250
页数：5
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