Leiomyoma and Leiomyosarcoma (Primary and Metastatic) of the Oral and Maxillofacial Region: A Clinicopathological and Immunohistochemical Study of 27 Cases

被引:0
作者
Gabriela Ribeiro de Araújo
Sara Ferreira dos Santos Costa
Ricardo Alves Mesquita
Ricardo Santiago Gomez
Jean Nunes dos Santos
Hélder Antônio Rebelo Pontes
Bruno Augusto Benevenuto de Andrade
Mário José Romañach
Michelle Agostini
Pablo Agustin Vargas
Cinthia Verônica Bardalez Lopez de Cáceres
Alan Roger Santos-Silva
Ana Carolina Prado Ribeiro
Thaís Bianca Brandão
Ramiro Alejandro Tomasi
Ruth Salomé Ferreyra
Oslei Paes de Almeida
Felipe Paiva Fonseca
机构
[1] Federal University of Minas Gerais,Department of Oral Surgery and Pathology, School of Dentistry
[2] Federal University of Bahia,Department of Oral Surgery and Pathology, School of Dentistry
[3] João de Barros Barreto University Hospital,Service of Oral Pathology
[4] Federal University of Pará,Department of Oral Diagnosis and Pathology, School of Dentistry
[5] Federal University of Rio de Janeiro,Oral Diagnosis Department (Pathology and Semiology Areas), Piracicaba Dental School
[6] University of Campinas,Dental Oncology Service
[7] Instituto do Câncer do Estado de São Paulo,Deparment of Pathology, Dental School
[8] National University of Córdoba,Department of Oral Biology and Oral Pathology, School of Dentistry
[9] University of Pretoria,undefined
来源
Head and Neck Pathology | 2022年 / 16卷
关键词
Angioleiomyoma; Leiomyoma; Leiomyosarcomas; Smooth muscle tumor; Oral cavity; Jaw;
D O I
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中图分类号
学科分类号
摘要
Smooth muscle neoplasms represent an important group of lesions which is rare in the oral cavity. Leiomyoma (LM) is benign smooth muscle/pericytic tumor usually presenting as non-aggressive neoplasm, while leiomyosarcoma (LMS) represents its malignant counterpart. The rarity of these lesions, together with its unspecific clinical presentation and a variable histopathological appearance, lead to a broad list of differential diagnoses, hampering their diagnoses. Therefore, in this study we describe the clinical and microscopic features of a series of oral and maxillofacial LMs and LMSs. A retrospective search from 2000 to 2019 was performed and all cases diagnosed as LM and LMS affecting the oral cavity and gnathic bones were retrieved. Clinical and demographic data were obtained from the patients’ pathology records, while microscopic features and immunohistochemistry were reviewed and completed when necessary to confirm the diagnoses. Twenty-two LMs and five LMSs were obtained. In the LM group, males predominated, with a mean age of 45.7 years. The upper lip was the most affected site, and 18 cases were classified as angioleiomyomas and four as solid LM. In the LMS group, females predominated, with a mean age of 47.6 years. The mandible was the most affected site. Diffuse proliferation of spindle cells, with necrosis and mitotic figures, were frequent microscopic findings. LMs and LMSs were positive for α-smooth muscle actin, HHF-35 and h-caldesmon. In conclusion, oral LM/LMS are uncommon neoplasms with the latter usually presenting as metastatic disease. H&E evaluation may be very suggestive of oral LMs, but h-caldesmon staining is strongly recommended to confirm LMS diagnosis.
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页码:294 / 303
页数:9
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