Synthesis and Cytotoxicity of Novel 4′-O-Demethylpodophyllotoxin Derivatives as Potential Anticancer Agents

被引：0
作者：
Dan-li Tian
Hong Chen
Gang Luo
Chun-po Liang
机构：
[1] Tianjin First Central Hospital,
[2] Logistics University of Chinese People’s Armed Police Forces,undefined
[3] Tianjin Medical University General Hospital,undefined
来源：
Chemistry of Natural Compounds | 2022年 / 58卷
关键词：
antitumor; 4′-; -demethylpodophyllotoxin; synthesis; cytotoxicity; structure–activity relationship; indole;
D O I：
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中图分类号：
学科分类号：
摘要：
Ten 4β-N-substituted derivatives of 4′-O-demethylpodophyllotoxin were designed by aldehydes reacting with 4′-O-demethylpodophyllotoxin. Their cytotoxicity against cancer cell lines (HeLa) was evaluated using the MTT assay. Compounds 7a–7d, 7f, 7g, and 7h exhibited pronounced stronger activity than that of the positive control etoposide (VP-16). 4β-N-Substituted derivatives of 4′-O-demethylpodophyllotoxin were worthy of further study with potential antitumor activity.
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页码：628 / 633
页数：5
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