Polyion complex micelle formed from tetraphenylethene containing block copolymer

被引：4

作者：

Lee S.M. ^{[1
]}

Jang W.-D. ^{[1
]}

机构：

[1] Department of Chemistry, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul

来源：

Biomaterials Research | / 21卷 / 1期

基金：

新加坡国家研究基金会;

关键词：

Aggregation induced emission; Dendrimer; Photodynamic therapy; Polyion complex; Polyoxazoline;

D O I：

10.1186/s40824-017-0103-9

中图分类号：

学科分类号：

摘要：

Background: Polymeric micelles attract great attention in drug delivery and therapeutics. Various types of block copolymers have been designed for the application in biomedical fields. If we can introduce additional functional groups to the block copolymers, we can achieve advanced applications. In this regards, we tried to introduce aggregation induced emission enhancement (AIE) unit in the block copolymer. Methods: The formation of polyion complex micelle was confirmed by dynamic light scattering and transmission electron microscopy. HeLa cells were incubated with polyion complex micelle and broad-band visible light using a halogen lamp (150 W) was irradiated to evaluate photocytotoxicity of polyion complex (PIC) micelle. Results: For the design of functional polymeric micelle, aggregation induced emission enhancement unit was introduced in the middle of block copolymer. We newly synthesized a new type block copolymer (PEG-TPE-PEI) possessing tetraphenylethene (TPE) group, as an AIE unit, in the middle of polymeric segments of PEG and PEI, which successfully formed PIC micelle with DP. The formation of PIC micelle was confirmed by dynamic light scattering, ζ potential measurement and transmission electron microscopy. Conclusions: PEG-TPE-PEI successfully formed PIC micelle by mixing with negatively charged dendrimer porphyrin. The PIC micelle exhibited photocytotoxicity upon illumination of broadband visible light. © 2017 The Author(s).

引用

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