A Continuous-Flow Fischer Indole Synthesis of 3-Methylindole in an Ionic Liquid

被引：0
作者：
Jiangang Yu
Jianguo Xu
Zhiqun Yu
Yi Jin
Jie Li
Yanwen Lv
机构：
[1] Quzhou University,College of Chemical and Material Engineering
[2] Zhejiang University of Technology,Key Laboratory of Pharmaceutical Engineering of Ministry of Education, College of Pharmaceutical Sciences
来源：
Journal of Flow Chemistry | 2017年 / 7卷
关键词：
Ionic liquid; flow chemistry; Fischer indole synthesis;
D O I：
暂无
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学科分类号：
摘要：
A continuous-flow reactor (Corning G1 reactor) was hereby introduced for Fischer indole synthesis of 3-methylindole by reaction of phenyl hydrazines and propylaldehyde. Stoichiometric Lewis acid, ZnCl2, was supplied as catalyst as well as remover of NH3 which generated during the indole ring formation. Ionic liquid ([EMIM][BF4]) was employed as solvent according to its high-temperature tolerance and good product distribution. After a straightforward extraction process, 3-methylindole could be obtained in a 95.3% yield (96.0% purity) under optimized conditions. Ionic liquid (IL) was then recovered by another extraction process, and the recovered IL acted nearly as efficiently as new IL for this Fischer indole reaction.
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页码：33 / 36
页数：3
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