The unfolded protein response in Alzheimer’s disease

被引：0
作者：
Víctor Hugo Cornejo
Claudio Hetz
机构：
[1] University of Chile,Biomedical Neuroscience Institute, Faculty of Medicine
[2] University of Chile,Center for Molecular Studies of the Cell, Institute of Biomedical Sciences
[3] Neurounion Biomedical Foundation,Department of Immunology and Infectious Diseases
[4] Harvard School of Public Health,Cellular and Molecular Biology Program, Institute of Biomedical Sciences
[5] University of Chile,undefined
来源：
Seminars in Immunopathology | 2013年 / 35卷
关键词：
Alzheimer’s disease; Amyloid-β; APP; Protein misfolding; ER stress; UPR;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by synaptic dysfunction and accumulation of amyloid-beta (Aβ) peptide, which are responsible for the progressive loss of memory. The mechanisms involved in neuron dysfunction in AD remain poorly understood. Recent evidence implicates the participation of adaptive responses to stress within the endoplasmic reticulum (ER) in the disease process, via a pathway known as the unfolded protein response (UPR). Here, we review the findings suggesting a functional role of ER stress in the etiology of AD. Possible therapeutic strategies to mitigate ER stress in the context of AD are discussed.
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页码：277 / 292
页数：15
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