Expression of p16 in Sinonasal Undifferentiated Carcinoma (SNUC) Without Associated Human Papillomavirus (HPV)

被引：41

作者：

Wadsworth B. ^{[1
]}

Bumpous J.M. ^{[2
]}

Martin A.W. ^{[3
]}

Nowacki M.R. ^{[3
]}

Jenson A.B. ^{[4
]}

Farghaly H. ^{[1
]}

机构：

[1] Department of Pathology and Laboratory Medicine, University of Louisville, Louisville, KY

[2] Department of Otolaryngology, University of Louisville, Louisville, KY

[3] Department of Pathology at Norton Hospital, Louisville, KY

[4] James Graham Brown Cancer Center, University of Louisville, Louisville, KY

来源：

Head and Neck Pathology | 2011年 / 5卷 / 4期

关键词：

Epstein Barr virus (EBV); Human papillomavirus (HPV); Poorly differentiated squamous cell carcinoma; Sinonasal carcinoma; Sinonasal undifferentiated carcinoma (SNUC);

D O I：

10.1007/s12105-011-0285-8

中图分类号：

学科分类号：

摘要：

Sinonasal undifferentiated carcinoma (SNUC) is an uncommon and highly aggressive neoplasm of the paranasal sinuses and nasal cavity. Its undifferentiated histologic appearance often requires immunohistochemical studies to distinguish it from other high-grade neoplasms. Due to the rarity of SNUC, its immunohistochemical staining profile has been incompletely characterized, and little work has been done on its expression of the markers for human papillomavirus (HPV). Our objective is to expand our knowledge of its immunophenotype and its association with HPV in order to define markers with mechanistic potential in the disease process, or of possible therapeutic importance. A total of five patients (one woman and four men) with SNUC, ranging in age from 26 to 75 years (mean 56.8 years) were compared to five patients (five men) with poorly differentiated squamous cell carcinoma (PDSCC), ranging in age from 53 to 75 years (mean 62.2 years). PDSCC was chosen as a control, given its well-reported immunohistochemical profile and negativity for HPV markers. The immunohistochemical panel included: CK7, CK19, EMA, NSE, chromogranin, p53, CK5/6, p63, CK14, S100, HMB-45, desmin, muscle specific actin, and CD45. Additionally, tests for p16, EBV, and HPV (subtypes 6, 11 16, 18) were performed. The diagnosis of SNUC was confirmed in all cases by histology and immunohistochemical stains. An interesting finding of strong diffuse positivity for p16 was noted in all SNUC cases, compared to only two of five PDSCC that were positive for p16. HPV DNA was not detected in any SNUC cases or any cases of PDSCC. All SNUC cases demonstrated over expression of p16 in the absence of HPV DNA expression. This may represent residual epithelial p16 staining, which is normally present in the sinonasal tract. Due to the rarity of SNUC, more cases will need to be evaluated to confirm the absence of HPV DNA. © 2011 Springer Science+Business Media, LLC.

引用

页码：349 / 354

页数：5

共 34 条

[1]

Frierson Jr. H.F., Sinonasal undifferentiated carcinoma, World Health Organization classification of tumors, (2005)

[2]

Pilch B.Z., Tumors of the upper respiratory tract, part B: larynx and trachea, Diagnostic Histopathology of Tumors, pp. 112-115, (2007)

[3]

Hunt J.L., Barnes L., Immunohistology of head and neck neoplasms, Diagnostic Immunohistochemistry, pp. 232-235, (2006)

[4]

Stelow E.B., Bellizzi A.M., Taneja K., Et al., NUT rearrangement in undifferentiated carcinomas of the upper aerodigestive tract, Am J Surg Pathol, 32, 6, pp. 828-834, (2008)

[5]

Desai P.C., Jaglal M.V., Gopal P., Et al., Human papillomavirus in metastatic squamous carcinoma from unknown primaries in the head and neck: a retrospective 7 year study, Exp Mol Pathol, 87, 2, pp. 94-98, (2009)

[6]

Frierson Jr. H.F., Mills S.E., Fechner R.E., Et al., Sinonasal undifferentiated carcinoma: an aggressive neoplasm derived from Schneiderian epithelium and distinct from olfactory neuroblastoma, Am J Surg Pathol, 10, 11, pp. 771-779, (1986)

[7]

Smith S.R., Som P., Fahmy A., Et al., A clinicopathological study of sinonasal neuroendocrine carcinoma and sinonasal undifferentiated carcinoma, Laryngoscope, 110, 10 PT 1, pp. 1617-1622, (2000)

[8]

Franchi A., Moroni M., Massi D., Et al., Sinonasal undifferentiated carcinoma, nasopharyngeal-type undifferentiated carcinoma, and keratinizing and nonkeratinizing squamous cell carcinoma express different cytokeratin patterns, Am J Surg Pathol, 26, 12, pp. 1597-1604, (2002)

[9]

Cerilli L.A., Holst V.A., Brandwein M.S., Et al., Sinonasal undifferentiated carcinoma: immunohistochemical profile and lack of EBV association, Am J Surg Pathol, 25, 2, pp. 156-163, (2001)

[10]

Dunn S.T., Clark G.D., Cannon T.C., Et al., Survey of sinonasal inverted papillomata for Epstein-Barr virus, Head Neck, 19, 2, pp. 98-106, (1997)

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