Acid-sensing ion channels 3: a potential therapeutic target for pain treatment in arthritis

被引：0
作者：
Feng-Lai Yuan
Fei-Hu Chen
Wei-Guo Lu
Xia Li
机构：
[1] The Third Hospital Affiliated to Nantong University,Department of Pharmacology, College of Pharmacy
[2] Anhui Medical University,undefined
来源：
Molecular Biology Reports | 2010年 / 37卷
关键词：
ASIC3; Inflammation; Pain; Hyperalgesia; DRG; Therapeutic target;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Acid-sensing ion channels 3 (ASIC3) is the most sensitive to such a pH change, predominantly distributed in the sensory peripheral nervous system, and strongly correlated with pain. Recently, there is increasing evidence that ASIC3 may contribute to the pathogenesis of chronic inflammatory pain diseases due to it is predominantly expressed in dorsal root ganglia (DRG) neurons making it a good candidate for a pain sensor. Elevated expression of ASIC3 was found in DRG of rodents with inflamed hind paws. In addition, it has been shown that ASIC3 gene knock-out mice (ASIC3−/−) exhibited no enhanced hyperalgesia in inflamed joint. All theses findings suggest that ASIC3 have important biological effects in inflammation that might be a promising therapeutic target for arthritis pain. In this review, we will briefly discuss the biological features of ASIC3 and summarize recent advances on the role of ASIC3 in the pathogenesis and treatment of arthritis pain.
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页码：3233 / 3238
页数：5
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