Elevated cerebral lactate: Implications in the pathogenesis of hepatic encephalopathy

被引：0
作者：
Cristina R. Bosoi
Christopher F. Rose
机构：
[1] Centre Hospitalier de l’Université de Montréal (CRCHUM),Hepato
来源：
Metabolic Brain Disease | 2014年 / 29卷
关键词：
Hepatic encephalopathy; Lactate; Brain edema; Ammonia;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Hepatic encephalopathy (HE), a complex neuropsychiatric syndrome, is a frequent complication of liver failure/disease. Increased concentrations of lactate are commonly observed in HE patients, in the systemic circulation, but also in the brain. Traditionally, increased cerebral lactate is considered a marker of energy failure/impairment however alterations in lactate homeostasis may also lead to a rise in brain lactate and result in neuronal dysfunction. The latter may involve the development of brain edema. This review will target the significance of increased cerebral lactate in the pathogenesis of HE.
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页码：919 / 925
页数：6
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