IFN-α induces a preferential long-lasting expression of MHC class I in human pancreatic beta cells

被引：0
作者：
Alexandra Coomans de Brachène
Reinaldo S. Dos Santos
Laura Marroqui
Maikel L. Colli
Lorella Marselli
Raghavendra G. Mirmira
Piero Marchetti
Decio L. Eizirik
机构：
[1] Université Libre de Bruxelles,ULB Center for Diabetes Research, Medical Faculty, Campus Erasme
[2] Miguel Hernández University of Elche,CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM) and Institute of Bioengineering
[3] University of Pisa,Department of Clinical and Experimental Medicine
[4] Indiana University School of Medicine,Department of Pediatrics, Medicine, and Physiology, Center for Diabetes and Metabolic Diseases
[5] School of Medicine,undefined
来源：
Diabetologia | 2018年 / 61卷
关键词：
IFN-α; JAK inhibitors; MHC class I; Pancreatic beta cells; Pancreatic islets; Type 1 diabetes;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
页码：636 / 640
页数：4
相关论文
共 33 条
[1]  
Richardson SJ(2016)Islet cell hyperexpression of HLA class I antigens: a defining feature in type 1 diabetes Diabetologia 59 2448-2458
[2]  
Rodriguez-Calvo T(1987)Immunoreactive alpha-interferon in insulin-secreting beta cells in type 1 diabetes mellitus Lancet 2 1423-1427
[3]  
Gerling IC(2012)Inflammation and type 1 diabetes Int Immunol 24 339-346
[4]  
Foulis AK(2017)Interferon-alpha mediates human beta cell HLA class I overexpression, endoplasmic reticulum stress and apoptosis, three hallmarks of early human type 1 diabetes Diabetologia 60 656-667
[5]  
Farquharson MA(2015)TYK2, a candidate gene for type 1 diabetes, modulates apoptosis and the innate immune response in human pancreatic beta-cells Diabetes 64 3808-3817
[6]  
Meager A(2017)Baricitinib: first global approval Drugs 77 697-704
[7]  
Bending D(2014)Innate immune activity is detected prior to seroconversion in children with HLA-conferred type 1 diabetes susceptibility Diabetes 63 2402-2414
[8]  
Zaccone P(2014)A type I interferon transcriptional signature precedes autoimmunity in children genetically at risk for type 1 diabetes Diabetes 63 2538-2550
[9]  
Cooke A(2001)IFN-gamma affects both the stability and the intracellular transport of class I MHC complexes J Interf Cytokine Res 21 199-208
[10]  
Marroqui L(2000)Function-related regulation of the stability of MHC proteins Biophys J 79 2305-2313
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