The role of noradrenalin in the pathogenesis of primary headaches

被引：0
作者：
A. Y. Sokolov
O. A. Lyubashina
A. V. Amelin
S. S. Panteleev
机构：
[1] Russian Academy of Sciences,Pavlov Institute of Physiology
[2] First Pavlov State Medical University,Valdman Institute of Pharmacology
[3] First Pavlov State Medical University,Department of Neurology and Neurosurgery
来源：
Neurochemical Journal | 2013年 / 7卷
关键词：
noradrenalin; adrenoceptors; headache; migraine; trigeminal nerve; endogenous antinociceptive system;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
This review is focused on the role of noradrenalin and its receptors in the pathogenesis of primary headaches, in particular, migraine headaches. The data are summarized on the involvement of different adrenoreceptors in the regulation of tone of cerebral vessels and modulation of transmission of nociceptive information in the trigeminovascular system and at the supraspinal level of the CNS. We discuss the pharmacodynamics of several adrenergic drugs that are used for prophylactic treatment of migraine headaches.
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页码：256 / 265
页数：9
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