Part II: Beneficial Effects of the Peroxynitrite Decomposition Catalyst FP15 in Murine Models of Arthritis and Colitis

[1] Singer II(1996)Expression of inducible nitric oxide synthase and nitrotyrosine in colonic epithelium in inflammatory bowel disease Gastroenterology 111 871-885

[2] Kawka DW(1998)Mercaptoethylguanidine, a combined inhibitor of nitric oxide synthase and peroxynitrite scavenger, reduces trinitrobenzene sulfonic acid-induced colonic damage in rats J. Pharmacol. Exp. Ther. 287 1048-1055

[3] Scott S(2001)Protective effects of M40403, a superoxide dismutase mimetic, in a rodent model of colitis Eur. J. Pharmacol. 432 79-89

[4] Zingarelli B(2001)Increased urinary nitrite, a marker of nitric oxide, in active inflammatory bowel disease Mediators Inflamm. 10 69-73

[5] Cuzzocrea S(2002)Colonic production of nitric oxide gas in ulcerative colitis, collagenous colitis and uninflamed bowel Scand. J. Gastroenterol. 37 183-188

[6] Szabo C(1995)Nitric oxide and its role in orthopaedic disease Clin. Orthop. 312 275-294

[7] Salzman AL(1997)Suppression of adjuvant arthritis and synovial macrophage inducible nitric oxide by N-iminoethyl-L-ornithine, a nitric oxide synthase inhibitor Inflammation 21 299-311

[8] Cuzzocrea S(1998)Collagen induced arthritis: reversal by mercaptoethylguanidine, a novel antiinflammatory agent with a combined mechanism of action J. Rheumatol. 25 1785-1793

[9] Mazzon E(2001)Amelioration of joint disease in a rat model of collagen-induced arthritis by M40403, a superoxide dismutase mimetic Arthritis Rheum. 44 2909-2921

[10] Dugo L(1997)Interleukin-17 up-regulation of nitric oxide production in human osteoarthritis cartilage Arthritis Rheum. 40 1050-1053

[1] Singer II(1996)Expression of inducible nitric oxide synthase and nitrotyrosine in colonic epithelium in inflammatory bowel disease Gastroenterology 111 871-885

[2] Kawka DW(1998)Mercaptoethylguanidine, a combined inhibitor of nitric oxide synthase and peroxynitrite scavenger, reduces trinitrobenzene sulfonic acid-induced colonic damage in rats J. Pharmacol. Exp. Ther. 287 1048-1055

[3] Scott S(2001)Protective effects of M40403, a superoxide dismutase mimetic, in a rodent model of colitis Eur. J. Pharmacol. 432 79-89

[4] Zingarelli B(2001)Increased urinary nitrite, a marker of nitric oxide, in active inflammatory bowel disease Mediators Inflamm. 10 69-73

[5] Cuzzocrea S(2002)Colonic production of nitric oxide gas in ulcerative colitis, collagenous colitis and uninflamed bowel Scand. J. Gastroenterol. 37 183-188

[6] Szabo C(1995)Nitric oxide and its role in orthopaedic disease Clin. Orthop. 312 275-294

[7] Salzman AL(1997)Suppression of adjuvant arthritis and synovial macrophage inducible nitric oxide by N-iminoethyl-L-ornithine, a nitric oxide synthase inhibitor Inflammation 21 299-311

[8] Cuzzocrea S(1998)Collagen induced arthritis: reversal by mercaptoethylguanidine, a novel antiinflammatory agent with a combined mechanism of action J. Rheumatol. 25 1785-1793

[9] Mazzon E(2001)Amelioration of joint disease in a rat model of collagen-induced arthritis by M40403, a superoxide dismutase mimetic Arthritis Rheum. 44 2909-2921

[10] Dugo L(1997)Interleukin-17 up-regulation of nitric oxide production in human osteoarthritis cartilage Arthritis Rheum. 40 1050-1053