Immune Cell Metabolism in Systemic Lupus Erythematosus

被引：0
作者：
Seung-Chul Choi
Anton A. Titov
Ramya Sivakumar
Wei Li
Laurence Morel
机构：
[1] University of Florida,Department of Pathology, Immunology, and Laboratory Medicine
[2] Beijing Normal University,Department of Biochemistry and Molecular Biology, Gene Engineering and Biotechnology, Beijing Key Laboratory
来源：
Current Rheumatology Reports | 2016年 / 18卷
关键词：
Lupus; Autoimmunity; T cells; B cells; Myeloid cells; Immunometabolism; Therapeutic targets;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Cellular metabolism represents a newly identified checkpoint of effector functions in the immune system. A solid body of work has characterized the metabolic requirements of normal T cells during activation and differentiation into polarized effector subsets. Similar studies have been initiated to characterize the metabolic requirements for B cells and myeloid cells. Only a few studies though have characterized the metabolism of immune cells in the context of autoimmune diseases. Here, we review what is known on the altered metabolic patterns of CD4+ T cells, B cells, and myeloid cells in lupus patients and lupus-prone mice and how they contribute to lupus pathogenesis. We also discuss how defects in immune metabolism in lupus can be targeted therapeutically.
引用
收藏
相关论文
共 231 条
[1]  
Frauwirth KA(2002)The CD28 signaling pathway regulates glucose metabolism Immunity 16 769-777
[2]  
Riley JL(2009)The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment Immunity 30 832-844
[3]  
Harris MH(2015)T cell metabolism drives immunity J Exp Med 212 1345-1360
[4]  
Delgoffe GM(2015)Targeting T cell metabolism for therapy Trends Immunol 36 71-80
[5]  
Kole TP(2012)Regulation of immune responses by mTOR Ann Rev Immunol 30 39-68
[6]  
Zheng Y(2013)Metabolic regulation of T lymphocytes Ann Rev Immunol 31 259-283
[7]  
Buck MD(2002)Metabolic switches of T-cell activation and apoptosis Antioxid Redox Signal 4 427-443
[8]  
O’Sullivan D(2009)Metabolic control of T cell activation and death in SLE Autoimmun Rev 8 184-189
[9]  
Pearce EL(2014)Metabolic control of the epigenome in systemic lupus erythematosus Autoimmunity 47 256-264
[10]  
O’Sullivan D(2016)Activation of mTOR (mechanistic target of rapamycin) in rheumatic diseases Nat Rev Rheumatol 12 169-182
12345678910