Preparation of protein microcapsules with narrow size distribution by sonochemical method

被引：0
作者：
Xuejun Cui
Bingnan Wang
Shuangling Zhong
Zhanfeng Li
Yongsheng Han
Hongyan Wang
Helmuth Moehwald
机构：
[1] Jilin University,College of Chemistry
[2] Jilin Agricultural University,College of Resources and Environment
[3] Max Planck Institute of Colloids and Interfaces,undefined
来源：
Colloid and Polymer Science | 2013年 / 291卷
关键词：
Protein microcapsules; Sonochemical method; Drug carriers; Microencapsulation; Narrow size distribution;
D O I：
暂无
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学科分类号：
摘要：
Protein microcapsules with narrow size distribution have been prepared by sonochemical method which is a simple, fast, environmental friendly and cost-effective method. The prepared microcapsules are composed of a water-insoluble core and an outer protein shell. The hydrophobic drugs could be encapsulated into protein microcapsules directly via sonochemical method by dissolving drugs in the nontoxic and edible vegetable oil before ultrasonication, which is a potential solution for drug resistance by hiding cytotoxic drugs in the carrier and allows for the delivery of high doses in relatively small volume. The size and size distribution of protein microcapsules are very important for their practical application. In this paper, the factors affecting the size and size distribution of protein microcapsules are investigated in detail. Moreover, confocal laser scanning microscopy and transmission electron microscopy confirmed that the protein microcapsules with narrow size distribution were obtained.
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页码：2271 / 2278
页数：7
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