Associations of genetically predicted IL-6 signaling with cardiovascular disease risk across population subgroups

被引：0
|
作者：
Marios K. Georgakis
Rainer Malik
Tom G. Richardson
Joanna M. M. Howson
Christopher D. Anderson
Stephen Burgess
G. Kees Hovingh
Martin Dichgans
Dipender Gill
机构：
[1] Massachusetts General Hospital,Center for Genomic Medicine
[2] Richard B. Simches Research Center,Program in Medical and Population Genetics
[3] Broad Institute of Harvard and the Massachusetts Institute of Technology,Genetics Department
[4] Institute for Stroke and Dementia Research (ISD),Department of Neurology
[5] University Hospital,Medical Research Council Biostatistics Unit
[6] Ludwig-Maximilians-University (LMU) Munich,Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care
[7] Novo Nordisk Research Centre,Department of Vascular Medicine, Academic Medical Center
[8] Brigham and Women’s Hospital,Global Chief Medical Office
[9] University of Cambridge,Department of Epidemiology and Biostatistics, School of Public Health, Medical School Building
[10] University of Cambridge,Clinical Pharmacology and Therapeutics Section
[11] Amsterdam University Medical Centers,undefined
[12] University of Amsterdam,undefined
[13] Novo Nordisk,undefined
[14] Munich Cluster for Systems Neurology (SyNergy),undefined
[15] German Centre for Neurodegenerative Diseases (DZNE),undefined
[16] St Mary’s Hospital,undefined
[17] Imperial College London,undefined
[18] Institute for Infection and Immunity,undefined
[19] St George’s,undefined
[20] University of London,undefined
来源：
BMC Medicine | / 20卷
关键词：
Inflammation; Interleukin-6; Atherosclerosis; Cardiovascular disease; C-reactive protein; Cytokines; Human genetics; Mendelian randomization;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
引用
收藏
相关论文
共 50 条
  • [1] Associations of genetically predicted IL-6 signaling with cardiovascular disease risk across population subgroups
    Georgakis, Marios K.
    Malik, Rainer
    Richardson, Tom G.
    Howson, Joanna M. M.
    Anderson, Christopher D.
    Burgess, Stephen
    Hovingh, G. Kees
    Dichgans, Martin
    Gill, Dipender
    BMC MEDICINE, 2022, 20 (01)
  • [2] Genetically Reduced IL-6 Attenuates Cardiovascular Disease Risk in Clonal Hematopoiesis
    Bick, Alexander G.
    Pirruccello, James
    Libby, Peter
    Kathiresan, Sekar
    Natarajan, Pradeep
    CIRCULATION, 2019, 140 (25) : E969 - E969
  • [3] Associations between cardiovascular disease risk factors and IL-6 and hsCRP levels in the elderly
    Nadrowski, Pawel
    Chudek, Jerzy
    Skrzypek, Michal
    Puzianowska-Kuznicka, Monika
    Mossakowska, Malgorzata
    Wiecek, Andrzej
    Zdrojewski, Tomasz
    Grodzicki, Tomasz
    Kozakiewicz, Krystyna
    EXPERIMENTAL GERONTOLOGY, 2016, 85 : 112 - 117
  • [4] Genetically Proxied IL-6 Receptor Inhibition and Coronary Artery Disease Risk in a Japanese Population
    Zhao, Sizheng Steven
    Gill, Dipender
    CLINICAL THERAPEUTICS, 2024, 46 (08) : 657 - 658
  • [5] Interaction between Fibrinogen and IL-6 Genetic Variants and Associations with Cardiovascular Disease Risk in the Cardiovascular Health Study
    Carty, Cara L.
    Heagerty, Patrick
    Heckbert, Susan R.
    Jarvik, Gail P.
    Lange, Leslie A.
    Cushman, Mary
    Tracy, Russell P.
    Reiner, Alexander P.
    ANNALS OF HUMAN GENETICS, 2010, 74 : 1 - 10
  • [6] The associations of interleukin-6 (IL-6) and downstream inflammatory markers with risk of cardiovascular disease: The Caerphilly Study
    Patterson, Christopher C.
    Smith, Anne E.
    Yarnell, John W. G.
    Rumley, Ann
    Ben-Shlomo, Yoav
    Lowe, Gordon D. O.
    ATHEROSCLEROSIS, 2010, 209 (02) : 551 - 557
  • [7] Associations Between Genetically Predicted Iron Status and Cardiovascular Disease Risk: A Mendelian Randomization Study
    Barad, Alexa
    Clark, Andrew G.
    Pressman, Eva K.
    O'Brien, Kimberly O.
    JOURNAL OF THE AMERICAN HEART ASSOCIATION, 2024, 13 (11):
  • [8] IL-6 and Cardiovascular Risk: A Narrative Review
    Mehta, Nehal N.
    Degoma, Emil
    Shapiro, Michael D.
    CURRENT ATHEROSCLEROSIS REPORTS, 2024, 27 (01)
  • [9] IL-6 haplotypes, inflammation, and risk for cardiovascular disease in a multiethnic dialysis cohort
    Liu, Yongmei
    Berthier-Schaad, Yvette
    Fallin, Margaret D.
    Fink, Nancy E.
    Tracy, Russell P.
    Klag, Michael J.
    Smith, Michael W.
    Coresh, Josef
    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2006, 17 (03): : 863 - 870
  • [10] Targeting IL-6 in patients at high cardiovascular risk
    Christoffersen, Mette
    Tybjaerg-Hansen, Anne
    LANCET, 2021, 397 (10289): : 2025 - 2027
12345