Two neurons mediate diet-restriction-induced longevity in C. elegans

被引:0
|
作者
Nicholas A. Bishop
Leonard Guarente
机构
[1] Massachusetts Institute of Technology,Department of Biology
[2] Cambridge,undefined
[3] Massachusetts 02139,undefined
[4] USA,undefined
来源
Nature | 2007年 / 447卷
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摘要
Dietary restriction extends lifespan and retards age-related disease in many species and profoundly alters endocrine function in mammals. However, no causal role of any hormonal signal in diet-restricted longevity has been demonstrated. Here we show that increased longevity of diet-restricted Caenorhabditis elegans requires the transcription factor gene skn-1 acting in the ASIs, a pair of neurons in the head. Dietary restriction activates skn-1 in these two neurons, which signals peripheral tissues to increase metabolic activity. These findings demonstrate that increased lifespan in a diet-restricted metazoan depends on cell non-autonomous signalling from central neuronal cells to non-neuronal body tissues, and suggest that the ASI neurons mediate diet-restriction-induced longevity by an endocrine mechanism.
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页码:545 / 549
页数:4
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