Parameters of the innate and adaptive immunity in cosmonauts after long-term space flight on board the international space station

被引：6

作者：

Morukov B.V. ^{[1
]}

Rykova M.P. ^{[1
]}

Antropova E.N. ^{[1
]}

Berendeeva T.A. ^{[1
]}

Ponomaryov S.A. ^{[1
]}

Larina I.M. ^{[1
]}

机构：

[1] Institute for Biomedical Problems, Russian Academy of Sciences, Moscow 123007

来源：

Human Physiology | 2010年 / 36卷 / 3期

关键词：

Adaptive immunity; Cytokines; Innate immunity; Space flights;

D O I：

10.1134/S0362119710030035

中图分类号：

学科分类号：

摘要：

The results of the study of the innate and adaptive immunity indicators in 12 cosmonauts who took part in long-term (128-215 days) expeditions on board the International Space Station (ISS) are presented. It was shown that the space flight may lead to deviations in the human immune system. A decrease in the functional activity of phagocytes, NK and T-cells, as well as in the ability of immunocompetent cells to synthesize cytokines were observed. Significant individual changes were observed in the immune system's response to a long-term space flight, which indicated an individual's predisposition to the development of immune reactivity disorders under varying gravitation conditions. © 2010 Pleiades Publishing, Ltd.

引用

页码：264 / 273

页数：9

共 20 条

[11] Janssens S., Beyart R., Role of Toll-Like Receptors in Pathogen Recognition, Clin. Microbiol. Rev., 16, (2003)
[12] Khaitov R.M., Leskov V.P., Immunity and Stress, Ros. Fiziol. Zh. Im. I.M. Sechenova, 87, 8, (2001)
[13] Koval'chuk L.V., Cheredeev A.N., Current Problems of Immune System Estimation in Humans, Immunologiya, 5, (1990)
[14] Thornton A.M., Shevach E.M., CD4<sup>+</sup>CD25<sup>+</sup> Immunoregulatory T-Cells Suppress Polyclonal T-cell Activation in Vitro by Inhibiting Interleukin 2 Production, J. Exp. Med., 188, (1998)
[15] Roncarolo M.G., Bacchetta R., Bordignon C., Et al., Type 1 Regulatory Cells, Immunol. Rev., 182, (2001)
[16] Shevach E.M., McHugh R.S., Thornton A.M., Et al., Control of Autoimmunity by Regulatory T-Cells, Adv. Exp. Med. Biol., 490, (2001)
[17] Chernykh E.R., Leplina O.Y., Tikhonova M.A., Et al., The T-cell Anergism Phenomenon in Surgical Sepsis, Med. Immunol., 5, 5-6, (2003)
[18] Kurganova E.V., Tikhonova M.A., Strel'tsova E.I., Et al., Regulatory T-Cells in Immunosupression Patogeny in Sepsis, Med. Immunol., 8, 2-3, (2006)
[19] Crucian B.E., Stowe R.P., Pierson D.L., Sams C.F., Immune System Dysregulation Following Short-vs. Long-Duration Space Flight, Aviat. Space Environ. Med., 79, (2008)
[20] Sepiashvili R.I., Functional System of Immune Homeostasis, Allergol. Immunopatol., 4, 2, (2003)

← 1 2 →