Parameters of the innate and adaptive immunity in cosmonauts after long-term space flight on board the international space station

被引：6

作者：

Morukov B.V. ^{[1
]}

Rykova M.P. ^{[1
]}

Antropova E.N. ^{[1
]}

Berendeeva T.A. ^{[1
]}

Ponomaryov S.A. ^{[1
]}

Larina I.M. ^{[1
]}

机构：

[1] Institute for Biomedical Problems, Russian Academy of Sciences, Moscow 123007

来源：

Human Physiology | 2010年 / 36卷 / 3期

关键词：

Adaptive immunity; Cytokines; Innate immunity; Space flights;

D O I：

10.1134/S0362119710030035

中图分类号：

学科分类号：

摘要：

The results of the study of the innate and adaptive immunity indicators in 12 cosmonauts who took part in long-term (128-215 days) expeditions on board the International Space Station (ISS) are presented. It was shown that the space flight may lead to deviations in the human immune system. A decrease in the functional activity of phagocytes, NK and T-cells, as well as in the ability of immunocompetent cells to synthesize cytokines were observed. Significant individual changes were observed in the immune system's response to a long-term space flight, which indicated an individual's predisposition to the development of immune reactivity disorders under varying gravitation conditions. © 2010 Pleiades Publishing, Ltd.

引用

页码：264 / 273

页数：9

共 20 条

[1] Konstantinova I.V., Sistema Immuniteta V Ekstremal'nykh Usloviyakh. Kosmicheskaya Immunologiya, (1988)
[2] Rykova M.P., Antropova E.N., Meshkov D.O., Results of Immunological Studies of Cosmonauts During Readaptation After SF, Orbital'naya Stantsiya MIR, 1, (2001)
[3] Konstantinova I.V., Rykova M.P., Lesnyak A.T., Antropova E.N., Immune Changes during Long-Duration Missions, J. Leukoc. Biol., 54, (1993)
[4] Rykova M., Meshkov D., Antropova E., Et al., The Effects of Microgravity on the Immune System, International Scientific Cooperation Onboard Mir (Int. Symposium), (2001)
[5] Meehan R.T., Whitson P., Sams C.F., The Role of Psychoneuroendocrine Factors on Spaceflight-Induced Immunological Alterations, J. Leukoc. Biol., 54, (1993)
[6] Stowe R.P., Sams C.F., Mehta S.K., Et al., Leukocyte Subsets and Neutrophil Function After Short-Term Spaceflight, J. Leukoc. Biol., (1999)
[7] Lebedev K.A., Ponyakina I.D., Kozachenko N.V., The Concept of the Norm in Estimating the Human Immunological Status, Fiziol. Chel., 15, 6, (1989)
[8] Lebedev K.A., Ponyakina I.D., Avdeeva V.S., Systemic Notion on the Quiet and Active States of the Immune System, Usp. Sovrem. Biol., 111, 2, (1991)
[9] Lebedev K.A., Ponyakina I.D., Immunologiya Obrazraspoznayushchikh Retseptorov (Integral'naya Immunologiya), (2009)
[10] Simbirtsev A.S., Toll proteins: Specific Receptors of Non-specific Immunity, Immunologiya, 6, (2005)

← 1 2 →