Synthesis, characterization, and antimicrobial activity of some novel thiazole clubbed 1,3,4-oxadiazoles

A series of novel thiazole clubbed 1,3,4-oxadiazole derivatives (5a–l) were efficiently synthesized and characterized by IR, 1H NMR, 13C NMR spectroscopy, and mass spectrometry. The newly synthesized compounds 5a–l were evaluated for their in vitro antibacterial activity against four bacterial and three fungal human pathogenic strains using conventional broth microdilution method. The results of antimicrobial study revealed that compounds 5c and 5i displayed the most potent antibacterial candidates, while compound 5f emerged as the most potent antifungal agent compared to standard drugs chloramphenicol and ketoconazole, respectively. On the basis of SAR studies, we observed that the presence of electron withdrawing groups at para position of phenyl ring enormously enhanced the antibacterial activity of newly synthesized compounds.