Anti-inflammatory effect of Acacia visco extracts in animal models

被引：11
作者：
Pedernera A.M. [1 ]
Guardia T. [1 ]
Guardia Calderón C.E. [2 ]
Rotelli A.E. [1 ]
De La Rocha N.E. [1 ]
Saad J.R. [3 ]
Lopez Verrilli M.A. [3 ]
Garcia Aseff S. [1 ]
Pelzer L.E. [1 ]
机构：
[1] Laboratorio de Farmacología, Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, San Luis 5700, Chacabuco y Pedernera
[2] Laboratorio de Bromatología, Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, San Luis 5700, Chacabuco y Pedernera
[3] INTEQUI-CONICET, Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, San Luis 5700, Chacabuco y Pedernera
来源：
Inflammopharmacology | 2010年 / 18卷 / 5期
关键词：
Acacia visco; Anti-inflammatory; Carrageenan-induced edema; Free-radical scavenging; Granuloma test; Phospholipase A[!sub]2[!/sub; Triterpenoids;
D O I：
10.1007/s10787-009-0028-6
中图分类号：
学科分类号：
摘要：
The aqueous and organic extracts of Acacia visco Lor. Ap Griseb (Fabaceae) were tested for anti-inflammatory activity in experimental models in rat. Besides, the free-radical scavenging capacity of extracts from A. visco was determined. The extracts revealed anti-inflammatory effect against carrageenan-induced oedema, phospholipase A2-induced oedema, cotton pellet-induced granuloma and they did not show acute toxic effect. Among the class of compounds characterized from A. visco leaves, the triterpenoid 20(29)-lupen-3β-ol (lupeol), 12-ursen-3β-ol (α-amyrin) and 12-oleanen-3β-ol (β-amyrin) may be mainly responsible for the pharmacological activities. © 2010 Birkhäuser Verlag, Basel/Switzerland.
引用
收藏
页码：253 / 260
页数：7
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