Anti-inflammatory effect of Acacia visco extracts in animal models

被引：11

作者：

Pedernera A.M. ^{[1
]}

Guardia T. ^{[1
]}

Guardia Calderón C.E. ^{[2
]}

Rotelli A.E. ^{[1
]}

De La Rocha N.E. ^{[1
]}

Saad J.R. ^{[3
]}

Lopez Verrilli M.A. ^{[3
]}

Garcia Aseff S. ^{[1
]}

Pelzer L.E. ^{[1
]}

机构：

[1] Laboratorio de Farmacología, Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, San Luis 5700, Chacabuco y Pedernera

[2] Laboratorio de Bromatología, Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, San Luis 5700, Chacabuco y Pedernera

[3] INTEQUI-CONICET, Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, San Luis 5700, Chacabuco y Pedernera

来源：

Inflammopharmacology | 2010年 / 18卷 / 5期

关键词：

Acacia visco; Anti-inflammatory; Carrageenan-induced edema; Free-radical scavenging; Granuloma test; Phospholipase A[!sub]2[!/sub; Triterpenoids;

D O I：

10.1007/s10787-009-0028-6

中图分类号：

学科分类号：

摘要：

The aqueous and organic extracts of Acacia visco Lor. Ap Griseb (Fabaceae) were tested for anti-inflammatory activity in experimental models in rat. Besides, the free-radical scavenging capacity of extracts from A. visco was determined. The extracts revealed anti-inflammatory effect against carrageenan-induced oedema, phospholipase A2-induced oedema, cotton pellet-induced granuloma and they did not show acute toxic effect. Among the class of compounds characterized from A. visco leaves, the triterpenoid 20(29)-lupen-3β-ol (lupeol), 12-ursen-3β-ol (α-amyrin) and 12-oleanen-3β-ol (β-amyrin) may be mainly responsible for the pharmacological activities. © 2010 Birkhäuser Verlag, Basel/Switzerland.

引用

页码：253 / 260

页数：7

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