Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19

被引:0
作者
Daniela Matuozzo
Estelle Talouarn
Astrid Marchal
Peng Zhang
Jeremy Manry
Yoann Seeleuthner
Yu Zhang
Alexandre Bolze
Matthieu Chaldebas
Baptiste Milisavljevic
Adrian Gervais
Paul Bastard
Takaki Asano
Lucy Bizien
Federica Barzaghi
Hassan Abolhassani
Ahmad Abou Tayoun
Alessandro Aiuti
Ilad Alavi Darazam
Luis M. Allende
Rebeca Alonso-Arias
Andrés Augusto Arias
Gokhan Aytekin
Peter Bergman
Simone Bondesan
Yenan T. Bryceson
Ingrid G. Bustos
Oscar Cabrera-Marante
Sheila Carcel
Paola Carrera
Giorgio Casari
Khalil Chaïbi
Roger Colobran
Antonio Condino-Neto
Laura E. Covill
Ottavia M. Delmonte
Loubna El Zein
Carlos Flores
Peter K. Gregersen
Marta Gut
Filomeen Haerynck
Rabih Halwani
Selda Hancerli
Lennart Hammarström
Nevin Hatipoğlu
Adem Karbuz
Sevgi Keles
Christèle Kyheng
Rafael Leon-Lopez
Jose Luis Franco
机构
[1] Laboratory of Human Genetics of Infectious Diseases,St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch
[2] Necker Branch,Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research
[3] INSERM U1163, Pediatric Hematology
[4] University Paris Cité,Immunology and Rheumatology Unit
[5] Imagine Institute,Department of Paediatric Immunohematology
[6] The Rockefeller University,Department of Biosciences and Nutrition
[7] NIAID,Research Center for Immunodeficiencies, Pediatrics Center of Excellence
[8] Helix,Genomics Center of Excellence
[9] Necker Hospital for Sick Children,Center for Genomic Discovery
[10] Assistance Publique-Hôpitaux de Paris (AP-HP),Infectious Diseases and Tropical Medicine Research Center
[11] IRCCS San Raffaele Scientific Institute,Department of Infectious Diseases and Tropical Medicine
[12] Karolinska Institute,Immunology Department
[13] Children’s Medical Center,Immunology Department
[14] Al Jalila Children’s Specialty Hospital,Department of Microbiology and Parasitology, Primary Immunodeficiencies Group, School of Medicine
[15] Mohammed Bin Rashid University of Medicine and Health Sciences,School of Microbiology
[16] San Raffaele Telethon Institute for Gene Therapy (SR-Tiget),Deparment of Internal Medicine, Division of Allergy and Immunology
[17] IRCSS San Raffaele Scientific Institute,Department of Infectious Diseases
[18] Vita-Salute San Raffaele University,Clinical Genomics
[19] Shahid Beheshti University of Medical Sciences,Department of Medicine, Centre for Hematology and Regenerative Medicine
[20] Loghman Hakim Hospital,Institute of Biomedical Research of IdiPAZ
[21] Shahid Beheshti University of Medical Sciences,Division of Genetics and Cell Biology
[22] University Hospital 12 de Octubre,School of Medicine
[23] Research Institute imas12 and Complutense University,Intensive Care Unit Department
[24] Hospital Universitario Central de Asturias; Health Research Institute of Principality of Asturias,Common and Rare Kidney Diseases
[25] University of Antioquia UdeA,Translational Immunology Research Group
[26] University of Antioquia UdeA,Genetics Department, Immunology Division
[27] Konya City Hospital,Department of Immunology, Institute of Biomedical Sciences
[28] The Immunodeficiency Unit,Biology Department
[29] Karolinska University Hospital,CIBER de Enfermedades Respiratorias
[30] Department of Laboratory Medicine,Faculty of Health Sciences
[31] Division of Clinical Immunology,Department of Internal Diseases and Pediatrics, Primary Immune Deficiency Research Laboratory, Centre for Primary Immunodeficiency Ghent
[32] IRCSS San Raffaele Scientific Institute, Research Institute for Medical and Health Sciences
[33] Karolinska Institute,Department of Pediatrics (Infectious Diseases), Istanbul Faculty of Medicine
[34] Universidad de La Sabana,Pediatric Infectious Diseases Unit
[35] University Hospital “La Paz”,Department of Pediatric Infectious Disease
[36] Unidad de Gestión Clínica de Cuidados Intensivos,Meram Medical Faculty, Pediatric Infectious Diseases Department
[37] Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC),Department of General Paediatrics
[38] Hospital Universitario Reina Sofía,Primary Immunodeficiencies Group, Department of Microbiology and Parasitology, School of Medicine
[39] Universidad de Córdoba (UCO),The Clinical Tuberculosis and Epidemiology Research Center
[40] Genome-Phenome Relationship,Department of Clinical Immunology and Infectious Diseases
[41] San Raffaele Hospital,Pediatric Respiratory Diseases Research Center
[42] Vita-Salute San Raffaele University,Department of Infectious Diseases and Immunity
[43] Avicenne Hospital,Consorcio Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (CIBERINFEC)
[44] Assistance Publique-Hôpitaux de Paris,Laboratory of Haematology
[45] Sorbonne University,Pediatric Infectious Diseases and Immunodeficiencies Unit
[46] INSERM UMR-S 1155,Infection and Immunity in Pediatric Patients Research Group
[47] Jeffrey Modell Diagnostic and Research Center for Primary Immunodeficiencies,Department of Biomedicine and Prevention
[48] Vall d’Hebron Research Institute (VHIR),Laboratory of Medical Genetics
[49] Vall d’Hebron University Hospital (HUVH),Department of Molecular Biology and Genetics
[50] Vall d’Hebron Barcelona Hospital Campus,Laboratory of Immunogenetics of Human Diseases
来源
Genome Medicine | / 15卷
关键词
Rare variants; COVID-19; Immunity; Type I interferon;
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