Assessment of left ventricular dyssynchrony by speckle tracking echocardiography in children with duchenne muscular dystrophy

被引：0
作者：
Nicolas Lanot
Marie Vincenti
Hamouda Abassi
Charlene Bredy
Audrey Agullo
Lucie Gamon
Thibault Mura
Kathleen Lavastre
Gregoire De La Villeon
Catherine Barrea
Pierre Meyer
François Rivier
Albano C. Meli
Jeremy Fauconnier
Olivier Cazorla
Alain Lacampagne
Pascal Amedro
机构：
[1] M3C Regional Reference CHD Center,Paediatric and Adult Cardiology Department
[2] CHU Montpellier,Epidemiology and Clinical Research Department
[3] PhyMedExp,Paediatric Cardiology and Rehabilitation Unit
[4] University of Montpellier,Epidemiology and Clinical Research Department
[5] CNRS,Paediatric and Congenital Cardiology Department
[6] INSERM,Paediatric Neurology
[7] CHU Montpellier,Department of Paediatric and Adult Congenital Cardiology
[8] CHU Montpellier,undefined
[9] Saint-Pierre Institute,undefined
[10] CHU Nimes,undefined
[11] Cliniques Universitaires Saint-Luc,undefined
[12] UCL University,undefined
[13] National Reference Center for Neuromuscular Diseases,undefined
[14] CHU Montpellier,undefined
[15] M3C National Reference Centre,undefined
[16] Bordeaux University Hospital,undefined
[17] Haut Lévêque Hospital,undefined
[18] University of Bordeaux,undefined
[19] INSERM,undefined
[20] Bordeaux Cardio-Thoracic Research Centre,undefined
[21] IHU Liryc,undefined
[22] Electrophysiology and Heart Modelling Institute,undefined
[23] Fondation Bordeaux Université,undefined
来源：
The International Journal of Cardiovascular Imaging | 2022年 / 38卷
关键词：
Cardiac dyssynchrony; Speckle tracking; DMD; Heart failure; Paediatrics;
D O I：
暂无
中图分类号：
学科分类号：
摘要：
Prognosis of Duchenne muscular dystrophy (DMD) is related to cardiac dysfunction. Two dimensional-speckle tracking echocardiography (2D-STE) has recently emerged as a non-invasive functional biomarker for early detection of DMD-related cardiomyopathy. This study aimed to determine, in DMD children, the existence of left ventricle (LV) dyssynchrony using 2D-STE analysis. This prospective controlled study enrolled 25 boys with DMD (mean age 11.0 ± 3.5 years) with normal LV ejection fraction and 50 age-matched controls. Three measures were performed to assess LV mechanical dyssynchrony: the opposing-wall delays (longitudinal and radial analyses), the modified Yu index, and the time-to-peak delays of each segment. Feasibility and reproducibility of 2D-STE dyssynchrony were evaluated. All three mechanical dyssynchrony criteria were significantly higher in the DMD group than in healthy subjects: (1) opposing-wall delays in basal inferoseptal to basal anterolateral segments (61.4 ± 45.3 ms vs. 18.3 ± 50.4 ms, P < 0.001, respectively) and in mid inferoseptal to mid anterolateral segments (58.6 ± 35.3 ms vs. 42.4 ± 36.4 ms, P < 0.05, respectively), (2) modified Yu index (33.3 ± 10.1 ms vs. 28.5 ± 8.1 ms, P < 0.05, respectively), and (3) most of time-to-peak values, especially in basal and mid anterolateral segments. Feasibility was excellent and reliability was moderate to excellent, with ICC values ranging from 0.49 to 0.97. Detection of LV mechanical dyssynchrony using 2D-STE analysis is an easily and reproducible method in paediatric DMD. The existence of an early LV mechanical dyssynchrony visualized using 2D-STE analysis in children with DMD before the onset of cardiomyopathy represents a perspective for future paediatric drug trials in the DMD-related cardiomyopathy prevention.
引用
收藏
页码：79 / 89
页数：10
相关论文
共 259 条
  • [11] Cnaan A(2004)Echocardiographic evaluation of cardiac dyssynchrony for predicting a favourable response to cardiac resynchronisation therapy Heart. 90 vi17-22
  • [12] Morgenroth LP(2007)Guidelines for cardiac pacing and cardiac resynchronization therapy: the task force for cardiac pacing and cardiac resynchronization therapy of the european society of cardiology. Developed in collaboration with the european heart rhythm association Eur Heart J. 28 2256-2295
  • [13] Ghelani SJ(2000)Hemodynamic implications of left bundle branch block J Electrocardiol 33 115-121
  • [14] Gordish-Dressman H(1998)Acute effects of intraoperative multisite ventricular pacing on left ventricular function and activation/contraction sequence in patients with depressed ventricular function J Cardiovasc Electrophysiol 9 13-21
  • [15] Connuck DM(2000)Ventricular contraction abnormalities in dilated cardiomyopathy: effect of biventricular pacing to correct interventricular dyssynchrony J Am Coll Cardiol 35 1221-1227
  • [16] Sleeper LA(2007)Perindopril preventive treatment on mortality in Duchenne muscular dystrophy: 10 years’ follow-up Am Heart J 154 596-602
  • [17] Colan SD(2018)Diagnosis and management of Duchenne muscular dystrophy, part 1: diagnosis, and neuromuscular, rehabilitation, endocrine, and gastrointestinal and nutritional management Lancet Neurol 17 251-267
  • [18] Cox GF(2010)Recommendations for quantification methods during the performance of a pediatric echocardiogram: a report from the pediatric measurements writing group of the american society of echocardiography pediatric and congenital heart disease council J Am Soc Echocardiogr Off Publ Am Soc Echocardiogr. 23 465-95
  • [19] Towbin JA(2015)Definitions for a common standard for 2D speckle tracking echocardiography: consensus document of the EACVI/ASE/industry task force to standardize deformation imaging J Am Soc Echocardiogr Off Publ Am Soc Echocardiogr 28 183-193
  • [20] Lowe AM(2020)A proposed method for the calculation of age-dependent QRS duration z-scores J Electrocardiol 58 132-134
12345678910