Zinc, Copper, Iron, and Chromium Concentrations in Young Patients with Type 2 Diabetes Mellitus

被引:0
作者
M. Basaki
M. Saeb
S. Nazifi
H. A. Shamsaei
机构
[1] Shiraz University,Department of Biochemistry, School of Veterinary Medicine
[2] Shiraz University,Department of Clinical Studies, School of Veterinary Medicine
[3] Shiraz University,Central Lab, School of Veterinary Medicine
来源
Biological Trace Element Research | 2012年 / 148卷
关键词
Trace elements; Zinc; Copper; Iron; Chromium; Type 2 diabetes mellitus;
D O I
暂无
中图分类号
学科分类号
摘要
Homeostasis of trace elements can be disrupted by diabetes mellitus. On the other hand, disturbance in trace element status in diabetes mellitus may contribute to the insulin resistance and development of diabetic complications. The aim of present study was to compare the concentration of essential trace elements, zinc, copper, iron, and chromium in serum of patients who have type 2 diabetes mellitus (n = 20) with those of nondiabetic control subjects (n = 20). The serum concentrations of zinc, copper, iron, and chromium were measured by means of an atomic absorption spectrophotometer (Shimadzu AA 670, Kyoto, Japan) after acid digestion. The results of this study showed that the mean values of zinc, copper, and chromium were significantly lower in the serum of patients with diabetes as compared to the control subjects (P < 0.05). Our results show that deficiency of some essential trace elements may play a role in the development of diabetes mellitus.
引用
收藏
页码:161 / 164
页数:3
相关论文
共 99 条
  • [1] Friederich M(2009)Diabetes, oxidative stress, nitric oxide and mitochondria function Curr Diabetes Rev 5 120-144
  • [2] Hansell P(2010)Insulin signaling meets mitochondria in metabolism Trends Endocrinol Metab 21 589-598
  • [3] Palm F(1983)Mediators of inflammation Annu Rev Immunol 1 335-359
  • [4] Cheng Z(2009)Altered metabolism of copper, zinc, and magnesium is associated with increased levels of glycated hemoglobin in patients with diabetes mellitus Metabolism 58 1477-1482
  • [5] Tseng Y(1983)Abnormal zinc metabolism in type II diabetes mellitus Am J Med 75 273-277
  • [6] White MF(1986)Role of zinc supplementation in type II diabetes mellitus Am J Med 81 63-68
  • [7] Larsen GL(1998)Is type II diabetes mellitus a disease of the innate immune system? Diabetologia 41 1241-1248
  • [8] Henson PM(2001)Potential antioxidant effects of zinc and chromium supplementation in people with type 2 diabetes mellitus J Am Coll Nutr 20 212-218
  • [9] Viktorínová A(1997)Elevated intakes of supplemental chromium improves glucose and insulin variables in individuals with type 2 diabetes Diabetes 46 1786-1791
  • [10] Toserová E(2008)Copper, chromium, manganese, iron, nickel, and zinc levels in biological samples of diabetes mellitus patients Biol Trace Elem Res 122 1-18